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dc.contributor.authorWilharm, Anneke
dc.contributor.authorBrigas, Helena C
dc.contributor.authorSandrock, Inga
dc.contributor.authorRibeiro, Miguel
dc.contributor.authorAmado, Tiago
dc.contributor.authorReinhardt, Annika
dc.contributor.authorDemera, Abdi
dc.contributor.authorHoenicke, Lisa
dc.contributor.authorStrowig, Till
dc.contributor.authorCarvalho, Tânia
dc.contributor.authorPrinz, Immo
dc.contributor.authorRibot, Julie C
dc.date.accessioned2020-10-05T10:45:12Z
dc.date.available2020-10-05T10:45:12Z
dc.date.issued2020-07-30
dc.identifier.citationMucosal Immunol. 2020 Jul 30. doi: 10.1038/s41385-020-0330-6. Epub ahead of print. Erratum in: Mucosal Immunol. 2020 Sep 29;: PMID: 32733025.en_US
dc.identifier.pmid32733025
dc.identifier.doi10.1038/s41385-020-0330-6
dc.identifier.urihttp://hdl.handle.net/10033/622497
dc.description.abstractγδT cells represent the majority of lymphocytes in several mucosal tissues where they contribute to tissue homoeostasis, microbial defence and wound repair. Here we characterise a population of interleukin (IL) 17-producing γδ (γδ17) T cells that seed the testis of naive C57BL/6 mice, expand at puberty and persist throughout adulthood. We show that this population is foetal-derived and displays a T-cell receptor (TCR) repertoire highly biased towards Vγ6-containing rearrangements. These γδ17 cells were the major source of IL-17 in the testis, whereas αβ T cells mostly provided interferon (IFN)-γ in situ. Importantly, testicular γδ17 cell homoeostasis was strongly dependent on the microbiota and Toll-like receptor (TLR4)/IL-1α/IL-23 signalling. We further found that γδ17 cells contributed to tissue surveillance in a model of experimental orchitis induced by intra-testicular inoculation of Listeria monocytogenes, as Tcrδ-/- and Il17-/- infected mice displayed higher bacterial loads than wild-type (WT) controls and died 3 days after infection. Altogether, this study identified a previously unappreciated foetal-derived γδ17 cell subset that infiltrates the testis at steady state, expands upon puberty and plays a crucial role in local tissue immune surveillance.en_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleMicrobiota-dependent expansion of testicular IL-17-producing Vγ6 γδ T cells upon puberty promotes local tissue immune surveillance.en_US
dc.typeArticleen_US
dc.identifier.eissn1935-3456
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalMucosal immunologyen_US
refterms.dateFOA2020-10-05T10:45:13Z
dc.source.journaltitleMucosal immunology
dc.source.countryUnited States


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