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dc.contributor.authorRyan, Daniel
dc.contributor.authorPrezza, Gianluca
dc.contributor.authorWestermann, Alexander J
dc.date.accessioned2020-10-08T12:35:36Z
dc.date.available2020-10-08T12:35:36Z
dc.date.issued2020-09-24
dc.identifier.citationBiol Chem. 2020 Sep 24:/j/bchm.ahead-of-print/hsz-2020-0230/hsz-2020-0230.xml. doi: 10.1515/hsz-2020-0230. Epub ahead of print.en_US
dc.identifier.pmid32881707
dc.identifier.doi10.1515/hsz-2020-0230
dc.identifier.urihttp://hdl.handle.net/10033/622500
dc.description.abstractBacteria employ noncoding RNAs to maintain cellular physiology, adapt global gene expression to fluctuating environments, sense nutrients, coordinate their interaction with companion microbes and host cells, and protect themselves against bacteriophages. While bacterial RNA research has made fundamental contributions to biomedicine and biotechnology, the bulk of our knowledge of RNA biology stems from the study of a handful of aerobic model species. In comparison, RNA research is lagging in many medically relevant obligate anaerobic species, in particular the numerous commensal bacteria comprising our gut microbiota. This review presents a guide to RNA-based regulatory mechanisms in the phylum Bacteroidetes, focusing on the most abundant bacterial genus in the human gut, Bacteroides spp. This includes recent case reports on riboswitches, an mRNA leader, cis- and trans-encoded small RNAs (sRNAs) in Bacteroides spp., and a survey of CRISPR-Cas systems across Bacteroidetes. Recent work from our laboratory now suggests the existence of hundreds of noncoding RNA candidates in Bacteroides thetaiotaomicron, the emerging model organism for functional microbiota research. Based on these collective observations, we predict mechanistic and functional commonalities and differences between Bacteroides sRNAs and those of other model bacteria, and outline open questions and tools needed to boost Bacteroidetes RNA research.en_US
dc.language.isoenen_US
dc.publisherWalter de Gruyteren_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectBacteroidesen_US
dc.subjectCRISPR-Casen_US
dc.subjectGibSen_US
dc.subjectmicrobiotaen_US
dc.subjectnoncoding RNAen_US
dc.subjectsmall RNAen_US
dc.titleAn RNA-centric view on gut Bacteroidetes.en_US
dc.typeArticleen_US
dc.typeOtheren_US
dc.identifier.eissn1437-4315
dc.contributor.departmentHIRI, Helmholtz-Institut für RNA-basierte Infektionsforschung, Josef-Shneider Strasse 2, 97080 Würzburg, Germany.en_US
dc.identifier.journalBiological chemistryen_US
refterms.dateFOA2020-10-08T12:35:37Z
dc.source.journaltitleBiological chemistry
dc.source.countryGermany


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