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dc.contributor.authorSchulte-Schrepping, Jonas
dc.contributor.authorReusch, Nico
dc.contributor.authorPaclik, Daniela
dc.contributor.authorBaßler, Kevin
dc.contributor.authorSchlickeiser, Stephan
dc.contributor.authorZhang, Bowen
dc.contributor.authorKrämer, Benjamin
dc.contributor.authorKrammer, Tobias
dc.contributor.authorBrumhard, Sophia
dc.contributor.authorBonaguro, Lorenzo
dc.contributor.authorDe Domenico, Elena
dc.contributor.authorWendisch, Daniel
dc.contributor.authorGrasshoff, Martin
dc.contributor.authorKapellos, Theodore S
dc.contributor.authorBeckstette, Michael
dc.contributor.authorPecht, Tal
dc.contributor.authorSaglam, Adem
dc.contributor.authorDietrich, Oliver
dc.contributor.authorMei, Henrik E
dc.contributor.authorSchulz, Axel R
dc.contributor.authorConrad, Claudia
dc.contributor.authorKunkel, Désirée
dc.contributor.authorVafadarnejad, Ehsan
dc.contributor.authorXu, Cheng-Jian
dc.contributor.authorHorne, Arik
dc.contributor.authorHerbert, Miriam
dc.contributor.authorDrews, Anna
dc.contributor.authorThibeault, Charlotte
dc.contributor.authorPfeiffer, Moritz
dc.contributor.authorHippenstiel, Stefan
dc.contributor.authorHocke, Andreas
dc.contributor.authorMüller-Redetzky, Holger
dc.contributor.authorHeim, Katrin-Moira
dc.contributor.authorMachleidt, Felix
dc.contributor.authorUhrig, Alexander
dc.contributor.authorBosquillon de Jarcy, Laure
dc.contributor.authorJürgens, Linda
dc.contributor.authorStegemann, Miriam
dc.contributor.authorGlösenkamp, Christoph R
dc.contributor.authorVolk, Hans-Dieter
dc.contributor.authorGoffinet, Christine
dc.contributor.authorLandthaler, Markus
dc.contributor.authorWyler, Emanuel
dc.contributor.authorGeorg, Philipp
dc.contributor.authorSchneider, Maria
dc.contributor.authorDang-Heine, Chantip
dc.contributor.authorNeuwinger, Nick
dc.contributor.authorKappert, Kai
dc.contributor.authorTauber, Rudolf
dc.contributor.authorCorman, Victor
dc.contributor.authorRaabe, Jan
dc.contributor.authorKaiser, Kim Melanie
dc.contributor.authorVinh, Michael To
dc.contributor.authorRieke, Gereon
dc.contributor.authorMeisel, Christian
dc.contributor.authorUlas, Thomas
dc.contributor.authorBecker, Matthias
dc.contributor.authorGeffers, Robert
dc.contributor.authorWitzenrath, Martin
dc.contributor.authorDrosten, Christian
dc.contributor.authorSuttorp, Norbert
dc.contributor.authorvon Kalle, Christof
dc.contributor.authorKurth, Florian
dc.contributor.authorHändler, Kristian
dc.contributor.authorSchultze, Joachim L
dc.contributor.authorAschenbrenner, Anna C
dc.contributor.authorLi, Yang
dc.contributor.authorNattermann, Jacob
dc.contributor.authorSawitzki, Birgit
dc.contributor.authorSaliba, Antoine-Emmanuel
dc.contributor.authorSander, Leif Erik
dc.date.accessioned2020-10-08T14:17:42Z
dc.date.available2020-10-08T14:17:42Z
dc.date.issued2020-08-05
dc.identifier.citationCell. 2020 Sep 17;182(6):1419-1440.e23. doi: 10.1016/j.cell.2020.08.001.en_US
dc.identifier.pmid32810438
dc.identifier.doi10.1016/j.cell.2020.08.001
dc.identifier.urihttp://hdl.handle.net/10033/622503
dc.description.abstractCoronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however, a subset of patients progress to severe disease and respiratory failure. The mechanism of protective immunity in mild forms and the pathogenesis of severe COVID-19 associated with increased neutrophil counts and dysregulated immune responses remain unclear. In a dual-center, two-cohort study, we combined single-cell RNA-sequencing and single-cell proteomics of whole-blood and peripheral-blood mononuclear cells to determine changes in immune cell composition and activation in mild versus severe COVID-19 (242 samples from 109 individuals) over time. HLA-DRhiCD11chi inflammatory monocytes with an interferon-stimulated gene signature were elevated in mild COVID-19. Severe COVID-19 was marked by occurrence of neutrophil precursors, as evidence of emergency myelopoiesis, dysfunctional mature neutrophils, and HLA-DRlo monocytes. Our study provides detailed insights into the systemic immune response to SARS-CoV-2 infection and reveals profound alterations in the myeloid cell compartment associated with severe COVID-19.en_US
dc.language.isoenen_US
dc.publisherElsevier /Cell Press)en_US
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/733100en_US
dc.rightsopenAccessen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectCOVID-19en_US
dc.subjectSARS-CoV-2en_US
dc.subjectdysfunctional neutrophilsen_US
dc.subjectemergency myelopoiesisen_US
dc.subjectimmune profilingen_US
dc.subjectmass cytometryen_US
dc.subjectmonocytesen_US
dc.subjectneutrophilsen_US
dc.subjectscRNA-seqen_US
dc.titleSevere COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment.en_US
dc.typeArticleen_US
dc.typeOtheren_US
dc.identifier.eissn1097-4172
dc.contributor.departmentBRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56,38106 Braunschweig, Germany.; HIRI, Helmholtz-Institut für RNA-basierte Infektionsforschung, Josef-Shneider Strasse 2, 97080 Würzburg, Germany.; CiiM, Zentrum für individualisierte Infektionsmedizin, Feodor-Lynen-Str.7, 30625 Hannover.; HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalCellen_US
dc.source.volume182
dc.source.issue6
dc.source.beginpage1419
dc.source.endpage1440.e23
refterms.dateFOA2020-10-08T14:17:43Z
dc.source.journaltitleCell
dc.source.countryUnited States


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