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dc.contributor.authorSandargo, Birthe
dc.contributor.authorChepkirui, Clara
dc.contributor.authorCheng, Tian
dc.contributor.authorChaverra-Muñoz, Lillibeth
dc.contributor.authorThongbai, Benjarong
dc.contributor.authorStadler, Marc
dc.contributor.authorHüttel, Stephan
dc.date.accessioned2020-10-13T12:47:18Z
dc.date.available2020-10-13T12:47:18Z
dc.date.issued2019-02-07
dc.identifier.citationBiotechnol Adv. 2019 Nov 1;37(6):107344. doi: 10.1016/j.biotechadv.2019.01.011. Epub 2019 Feb 7.en_US
dc.identifier.pmid30738916
dc.identifier.doi10.1016/j.biotechadv.2019.01.011
dc.identifier.urihttp://hdl.handle.net/10033/622510
dc.description.abstractThe Basidiomycota constitutes the second largest higher taxonomic group of the Fungi after the Ascomycota and comprises over 30.000 species. Mycelial cultures of Basidiomycota have already been studied since the 1950s for production of antibiotics and other beneficial secondary metabolites. Despite the fact that unique and selective compounds like pleuromutilin were obtained early on, it took several decades more until they were subjected to a systematic screening for antimicrobial and anticancer activities. These efforts led to the discovery of the strobilurins and several hundreds of further compounds that mainly constitute terpenoids. In parallel the traditional medicinal mushrooms of Asia were also studied intensively for metabolite production, aimed at finding new therapeutic agents for treatment of various diseases including metabolic disorders and the central nervous system. While the evaluation of this organism group has in general been more tedious as compared to the Ascomycota, the chances to discover new metabolites and to develop them further to candidates for drugs, agrochemicals and other products for the Life Science industry have substantially increased over the past decade. This is owing to the revolutionary developments in -OMICS techniques, bioinformatics, analytical chemistry and biotechnological process technology, which are steadily being developed further. On the other hand, the new developments in polythetic fungal taxonomy now also allow a more concise selection of previously untapped organisms. The current review is dedicated to summarize the state of the art and to give an outlook to further developments.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectAntibioticsen_US
dc.subjectAnticancer agentsen_US
dc.subjectBioprospectingen_US
dc.subjectBiotechnologyen_US
dc.subjectMedicinal mushroomsen_US
dc.subjectNatural productsen_US
dc.subjectNeurotrophic agentsen_US
dc.titleBiological and chemical diversity go hand in hand: Basidiomycota as source of new pharmaceuticals and agrochemicals.en_US
dc.typeReviewen_US
dc.typeOtheren_US
dc.identifier.eissn1873-1899
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalBiotechnology advancesen_US
dc.source.volume37
dc.source.issue6
dc.source.beginpage107344
dc.source.endpage
refterms.dateFOA2020-10-13T12:47:18Z
dc.source.journaltitleBiotechnology advances
dc.source.countryEngland


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