Langat virus infection affects hippocampal neuron morphology and function in mice without disease signs.
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Authors
Cornelius, Angela D AHosseini, Shirin
Schreier, Sarah
Fritzsch, David
Weichert, Loreen
Michaelsen-Preusse, Kristin
Fendt, Markus
Kröger, Andrea
Issue Date
2020-09-20
Metadata
Show full item recordAbstract
To compare the effect of low and high viral replication in the brain, wildtype and Irf-7-/- mice were infected with Langat virus (LGTV), which belongs to the TBEV-serogroup. The viral burden was analyzed in the olfactory bulb and the hippocampus. Open field, elevated plus maze, and Morris water maze experiments were performed to determine the impact on anxiety-like behavior, learning, and memory formation. Spine density of hippocampal neurons and activation of microglia and astrocytes were analyzed.Citation
Neuroinflammation. 2020 Sep 20;17(1):278. doi: 10.1186/s12974-020-01951-w.Affiliation
TWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH,Feodor-Lynen Str. 7, 30625 Hannover, Germany.Publisher
BioMed CentralJournal
Journal of neuroinflammationPubMed ID
32951602Type
ArticleLanguage
enEISSN
1742-2094ae974a485f413a2113503eed53cd6c53
10.1186/s12974-020-01951-w
Scopus Count
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- Creative Commons
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