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Langat virus infection affects hippocampal neuron morphology and function in mice without disease signs.

dc.contributor.authorCornelius, Angela D A
dc.contributor.authorHosseini, Shirin
dc.contributor.authorSchreier, Sarah
dc.contributor.authorFritzsch, David
dc.contributor.authorWeichert, Loreen
dc.contributor.authorMichaelsen-Preusse, Kristin
dc.contributor.authorFendt, Markus
dc.contributor.authorKröger, Andrea
dc.date.accessioned2020-10-19T13:16:03Z
dc.date.available2020-10-19T13:16:03Z
dc.date.issued2020-09-20
dc.identifier.citationNeuroinflammation. 2020 Sep 20;17(1):278. doi: 10.1186/s12974-020-01951-w.en_US
dc.identifier.pmid32951602
dc.identifier.doi10.1186/s12974-020-01951-w
dc.identifier.urihttp://hdl.handle.net/10033/622520
dc.description.abstractTo compare the effect of low and high viral replication in the brain, wildtype and Irf-7-/- mice were infected with Langat virus (LGTV), which belongs to the TBEV-serogroup. The viral burden was analyzed in the olfactory bulb and the hippocampus. Open field, elevated plus maze, and Morris water maze experiments were performed to determine the impact on anxiety-like behavior, learning, and memory formation. Spine density of hippocampal neurons and activation of microglia and astrocytes were analyzed.en_US
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectHippocampusen_US
dc.subjectInapparent infectionen_US
dc.subjectLangat virusen_US
dc.subjectLearning and memoryen_US
dc.subjectTick-borne encephalitis virusen_US
dc.subjectType I interferonen_US
dc.titleLangat virus infection affects hippocampal neuron morphology and function in mice without disease signs.en_US
dc.typeArticleen_US
dc.identifier.eissn1742-2094
dc.contributor.departmentTWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH,Feodor-Lynen Str. 7, 30625 Hannover, Germany.en_US
dc.identifier.journalJournal of neuroinflammationen_US
dc.source.volume17
dc.source.issue1
dc.source.beginpage278
dc.source.endpage
refterms.dateFOA2020-10-19T13:16:04Z
dc.source.journaltitleJournal of neuroinflammation
dc.source.countryEngland


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