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dc.contributor.authorGünther, Thomas
dc.contributor.authorCzech-Sioli, Manja
dc.contributor.authorIndenbirken, Daniela
dc.contributor.authorRobitaille, Alexis
dc.contributor.authorTenhaken, Peter
dc.contributor.authorExner, Martin
dc.contributor.authorOttinger, Matthias
dc.contributor.authorFischer, Nicole
dc.contributor.authorGrundhoff, Adam
dc.contributor.authorBrinkmann, Melanie M
dc.date.accessioned2020-10-26T14:07:32Z
dc.date.available2020-10-26T14:07:32Z
dc.date.issued2020-10-04
dc.identifier.citationEMBO Mol Med. 2020 Oct 4:e13296. doi: 10.15252/emmm.202013296.en_US
dc.identifier.pmid33012091
dc.identifier.doi10.15252/emmm.202013296
dc.identifier.urihttp://hdl.handle.net/10033/622537
dc.description.abstractWe describe a multifactorial investigation of a SARS-CoV-2 outbreak in a large meat processing complex in Germany. Infection event timing, spatial, climate and ventilation conditions in the processing plant, sharing of living quarters and transport, and viral genome sequences were analyzed. Our results suggest that a single index case transmitted SARS-CoV-2 to co-workers over distances of more than 8 meters, within a confined work area in which air is constantly recirculated and cooled. Viral genome sequencing shows that all cases share a set of mutations representing a novel sub-branch in the SARS-CoV-2 C20 clade. We identified the same set of mutations in samples collected in the time period between this initial infection cluster and a subsequent outbreak within the same factory, with the largest number of confirmed SARS-CoV-2 cases in a German meat processing facility reported so far. Our results indicate climate conditions, fresh air exchange rates, and airflow as factors that can promote efficient spread of SARS-CoV-2 via long distances and provide insights into possible requirements for pandemic mitigation strategies in industrial workplace settings.en_US
dc.language.isoenen_US
dc.publisherEMBO Pressen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectAerosol transmissionen_US
dc.subjectSARS-CoV-2 super spreading eventen_US
dc.subjectmeat processing plant outbreaken_US
dc.subjectviral genome sequencingen_US
dc.titleSARS-CoV-2 outbreak investigation in a German meat processing plant.en_US
dc.typeArticleen_US
dc.identifier.eissn1757-4684
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalEMBO molecular medicineen_US
dc.source.beginpagee13296
dc.source.endpage
refterms.dateFOA2020-10-26T14:07:33Z
dc.source.journaltitleEMBO molecular medicine
dc.source.countryEngland


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