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Abassi and Cicin-Sain.pdf
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Issue Date
2020-10-08
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Cytomegaloviruses (CMV) coevolve with their hosts and latently persist in the vast majority of adult mammals. Therefore, persistent T-cell responses to CMV antigens during virus latency offer a fascinating perspective on the evolution of the T-cell repertoire in natural settings. We addressed here the life-long interactions between CMV antigens presented on MHC-I molecules and the CD8 T-cell response. We present the mechanistic evidence from the murine model of CMV infection and put it in context of clinical laboratory results. We will highlight the remarkable parallels in T-cell responses between the two biological systems, and focus in particular on memory inflation as a result of competitive processes, both between viral antigenic peptides and between T-cell receptors on the host’s cytotoxic lymphocytesCitation
Curr Opin Virol. 2020 Oct 8;44:162-168. doi: 10.1016/j.coviro.2020.08.007.Affiliation
HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.Publisher
ElsevierJournal
Current opinion in virologyPubMed ID
33039898Type
ArticleOther
Language
enEISSN
1879-6265ae974a485f413a2113503eed53cd6c53
10.1016/j.coviro.2020.08.007
Scopus Count
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