The avid competitors of memory inflation.
dc.contributor.author | Abassi, Leila | |
dc.contributor.author | Cicin-Sain, Luka | |
dc.date.accessioned | 2020-10-28T12:41:56Z | |
dc.date.available | 2020-10-28T12:41:56Z | |
dc.date.issued | 2020-10-08 | |
dc.identifier.citation | Curr Opin Virol. 2020 Oct 8;44:162-168. doi: 10.1016/j.coviro.2020.08.007. | en_US |
dc.identifier.pmid | 33039898 | |
dc.identifier.doi | 10.1016/j.coviro.2020.08.007 | |
dc.identifier.uri | http://hdl.handle.net/10033/622544 | |
dc.description.abstract | Cytomegaloviruses (CMV) coevolve with their hosts and latently persist in the vast majority of adult mammals. Therefore, persistent T-cell responses to CMV antigens during virus latency offer a fascinating perspective on the evolution of the T-cell repertoire in natural settings. We addressed here the life-long interactions between CMV antigens presented on MHC-I molecules and the CD8 T-cell response. We present the mechanistic evidence from the murine model of CMV infection and put it in context of clinical laboratory results. We will highlight the remarkable parallels in T-cell responses between the two biological systems, and focus in particular on memory inflation as a result of competitive processes, both between viral antigenic peptides and between T-cell receptors on the host’s cytotoxic lymphocytes | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.title | The avid competitors of memory inflation. | en_US |
dc.type | Article | en_US |
dc.type | Other | en_US |
dc.identifier.eissn | 1879-6265 | |
dc.contributor.department | HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany. | en_US |
dc.identifier.journal | Current opinion in virology | en_US |
dc.source.volume | 44 | |
dc.source.beginpage | 162 | |
dc.source.endpage | 168 | |
dc.source.journaltitle | Current opinion in virology | |
dc.source.country | Netherlands |