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dc.contributor.authorAbassi, Leila
dc.contributor.authorCicin-Sain, Luka
dc.date.accessioned2020-10-28T12:41:56Z
dc.date.available2020-10-28T12:41:56Z
dc.date.issued2020-10-08
dc.identifier.citationCurr Opin Virol. 2020 Oct 8;44:162-168. doi: 10.1016/j.coviro.2020.08.007.en_US
dc.identifier.pmid33039898
dc.identifier.doi10.1016/j.coviro.2020.08.007
dc.identifier.urihttp://hdl.handle.net/10033/622544
dc.description.abstractCytomegaloviruses (CMV) coevolve with their hosts and latently persist in the vast majority of adult mammals. Therefore, persistent T-cell responses to CMV antigens during virus latency offer a fascinating perspective on the evolution of the T-cell repertoire in natural settings. We addressed here the life-long interactions between CMV antigens presented on MHC-I molecules and the CD8 T-cell response. We present the mechanistic evidence from the murine model of CMV infection and put it in context of clinical laboratory results. We will highlight the remarkable parallels in T-cell responses between the two biological systems, and focus in particular on memory inflation as a result of competitive processes, both between viral antigenic peptides and between T-cell receptors on the host’s cytotoxic lymphocytesen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleThe avid competitors of memory inflation.en_US
dc.typeArticleen_US
dc.typeOtheren_US
dc.identifier.eissn1879-6265
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalCurrent opinion in virologyen_US
dc.source.volume44
dc.source.beginpage162
dc.source.endpage168
dc.source.journaltitleCurrent opinion in virology
dc.source.countryNetherlands


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