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dc.contributor.authorKnittel, Vanessa
dc.contributor.authorSadana, Pooja
dc.contributor.authorSeekircher, Stephanie
dc.contributor.authorStolle, Anne-Sophie
dc.contributor.authorKörner, Britta
dc.contributor.authorVolk, Marcel
dc.contributor.authorJeffries, Cy M
dc.contributor.authorSvergun, Dmitri I
dc.contributor.authorHeroven, Ann Kathrin
dc.contributor.authorScrima, Andrea
dc.contributor.authorDersch, Petra
dc.date.accessioned2020-11-02T10:22:31Z
dc.date.available2020-11-02T10:22:31Z
dc.date.issued2020-09-23
dc.identifier.citationLoS Pathog. 2020 Sep 23;16(9):e1008552. doi: 10.1371/journal.ppat.1008552.en_US
dc.identifier.pmid32966346
dc.identifier.doi10.1371/journal.ppat.1008552
dc.identifier.urihttp://hdl.handle.net/10033/622548
dc.description.abstractType VI secretion systems (T6SSs) are complex macromolecular injection machines which are widespread in Gram-negative bacteria. They are involved in host-cell interactions and pathogenesis, required to eliminate competing bacteria, or are important for the adaptation to environmental stress conditions. Here we identified regulatory elements controlling the T6SS4 of Yersinia pseudotuberculosis and found a novel type of hexameric transcription factor, RovC. RovC directly interacts with the T6SS4 promoter region and activates T6SS4 transcription alone or in cooperation with the LysR-type regulator RovM. A higher complexity of regulation was achieved by the nutrient-responsive global regulator CsrA, which controls rovC expression on the transcriptional and post-transcriptional level. In summary, our work unveils a central mechanism in which RovC, a novel key activator, orchestrates the expression of the T6SS weapons together with a global regulator to deploy the system in response to the availability of nutrients in the species' native environment.en_US
dc.language.isoenen_US
dc.publisherPLOSen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleRovC - a novel type of hexameric transcriptional activator promoting type VI secretion gene expression.en_US
dc.typeArticleen_US
dc.identifier.eissn1553-7374
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalPLoS pathogensen_US
dc.source.volume16
dc.source.issue9
dc.source.beginpagee1008552
dc.source.endpage
refterms.dateFOA2020-11-02T10:22:32Z
dc.source.journaltitlePLoS pathogens
dc.source.countryUnited States


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Attribution-NonCommercial-ShareAlike 4.0 International
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