Development and external validation of a clinical prediction model for MRSA carriage at hospital admission in Southeast Lower Saxony, Germany.
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Akmatov, Manas K
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AbstractIn countries with low endemic Methicillin-resistant Staphylococcus aureus (MRSA) prevalence, identification of risk groups at hospital admission is considered more cost-effective than universal MRSA screening. Predictive statistical models support the selection of suitable stratification factors for effective screening programs. Currently, there are no universal guidelines in Germany for MRSA screening. Instead, a list of criteria is available from the Commission for Hospital Hygiene and Infection Prevention (KRINKO) based on which local strategies should be adopted. We developed and externally validated a model for individual prediction of MRSA carriage at hospital admission in the region of Southeast Lower Saxony based on two prospective studies with universal screening in Braunschweig (n = 2065) and Wolfsburg (n = 461). Logistic regression was used for model development. The final model (simplified to an unweighted score) included history of MRSA carriage, care dependency and cancer treatment. In the external validation dataset, the score showed a sensitivity of 78.4% (95% CI: 64.7-88.7%), and a specificity of 70.3% (95% CI: 65.0-75.2%). Of all admitted patients, 25.4% had to be screened if the score was applied. A model based on KRINKO criteria showed similar sensitivity but lower specificity, leading to a considerably higher proportion of patients to be screened (49.5%).
CitationSci Rep. 2020 Oct 22;10(1):17998. doi: 10.1038/s41598-020-75094-6.
AffiliationHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.
PublisherNature publishing group (NPG)
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International
- A predictive model for identifying surgical patients at risk of methicillin-resistant Staphylococcus aureus carriage on admission.
- Authors: Harbarth S, Sax H, Uckay I, Fankhauser C, Agostinho A, Christenson JT, Renzi G, Schrenzel J, Pittet D
- Issue date: 2008 Nov
- Prevalence and risk factors for carriage of methicillin-resistant Staphylococcus aureus at admission to the intensive care unit: results of a multicenter study.
- Authors: Lucet JC, Chevret S, Durand-Zaleski I, Chastang C, Régnier B, Multicenter Study Group.
- Issue date: 2003 Jan 27
- Variable performance of models for predicting methicillin-resistant Staphylococcus aureus carriage in European surgical wards.
- Authors: Lee AS, Pan A, Harbarth S, Patroni A, Chalfine A, Daikos GL, Garilli S, Martínez JA, Cooper BS, MOSAR-04 Study Team.
- Issue date: 2015 Feb 27
- [Generalized or targeted screening for carriage of MRSA on admission to a geriatric hospital].
- Authors: Myngheer N, Schuermans A, Flamaing J
- Issue date: 2011 Sep
- Clustering and risk factors of methicillin-resistant Staphylococcus aureus carriage in two Italian long-term care facilities.
- Authors: Brugnaro P, Fedeli U, Pellizzer G, Buonfrate D, Rassu M, Boldrin C, Parisi SG, Grossato A, Palù G, Spolaore P
- Issue date: 2009 Jun