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dc.contributor.authorGálvez, Eric J C
dc.contributor.authorIljazovic, Aida
dc.contributor.authorAmend, Lena
dc.contributor.authorLesker, Till Robin
dc.contributor.authorRenault, Thibaud
dc.contributor.authorThiemann, Sophie
dc.contributor.authorHao, Lianxu
dc.contributor.authorRoy, Urmi
dc.contributor.authorGronow, Achim
dc.contributor.authorCharpentier, Emmanuelle
dc.contributor.authorStrowig, Till
dc.date.accessioned2020-11-11T09:34:05Z
dc.date.available2020-11-11T09:34:05Z
dc.date.issued2020-10-13
dc.identifier.citationCell Host Microbe. 2020 Oct 13:S1931-3128(20)30515-1. doi: 10.1016/j.chom.2020.09.012. Epub ahead of print.en_US
dc.identifier.pmid33113351
dc.identifier.doi10.1016/j.chom.2020.09.012
dc.identifier.urihttp://hdl.handle.net/10033/622573
dc.description.abstractPrevotella spp. are a dominant bacterial genus within the human gut. Multiple Prevotella spp. co-exist in some individuals, particularly those consuming plant-based diets. Additionally, Prevotella spp. exhibit variability in the utilization of diverse complex carbohydrates. To investigate the relationship between Prevotella competition and diet, we isolated Prevotella species from the mouse gut, analyzed their genomes and transcriptomes in vivo, and performed competition experiments between species in mice. Diverse dominant Prevotella species compete for similar metabolic niches in vivo, which is linked to the upregulation of specific polysaccharide utilization loci (PULs). Complex plant-derived polysaccharides are required for Prevotella spp. expansion, with arabinoxylans having a prominent impact on species abundance. The most dominant Prevotella species encodes a specific tandem-repeat trsusC/D PUL that enables arabinoxylan utilization and is conserved in human Prevotella copri strains, particularly among those consuming a vegan diet. These findings suggest that efficient (arabino)xylan-utilization is a factor contributing to Prevotella dominance.en_US
dc.language.isoenen_US
dc.publisherElsevier (CellPress)en_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectPrevotella spp.en_US
dc.subjectanaerobic microbiologyen_US
dc.subjectcompetitionen_US
dc.subjectdieten_US
dc.subjectfiber degradationen_US
dc.subjectgut microbiomeen_US
dc.subjectmetagenomicsen_US
dc.subjectpolysaccharidesen_US
dc.titleDistinct Polysaccharide Utilization Determines Interspecies Competition between Intestinal Prevotella spp.en_US
dc.typeArticleen_US
dc.identifier.eissn1934-6069
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalCell host & microbeen_US
dc.source.journaltitleCell host & microbe
dc.source.countryUnited States


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