Host immune genetic variations influence the risk of developing acute myeloid leukaemia: results from the NuCLEAR consortium.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsSánchez-Maldonado, J M
Ter Horst, R
López-Nevot, M A
Rodríguez-Sevilla, J J
Fonseca, J E
Netea, M G
MetadataShow full item record
AbstractThe purpose of this study was to conduct a two-stage case control association study including 654 acute myeloid leukaemia (AML) patients and 3477 controls ascertained through the NuCLEAR consortium to evaluate the effect of 27 immune-related single nucleotide polymorphisms (SNPs) on AML risk. In a pooled analysis of cohort studies, we found that carriers of the IL13rs1295686A/A genotype had an increased risk of AML (PCorr = 0.0144) whereas carriers of the VEGFArs25648T allele had a decreased risk of developing the disease (PCorr = 0.00086). In addition, we found an association of the IL8rs2227307 SNP with a decreased risk of developing AML that remained marginally significant after multiple testing (PCorr = 0.072). Functional experiments suggested that the effect of the IL13rs1295686 SNP on AML risk might be explained by its role in regulating IL1Ra secretion that modulates AML blast proliferation. Likewise, the protective effect of the IL8rs2227307 SNP might be mediated by TLR2-mediated immune responses that affect AML blast viability, proliferation and chemorresistance. Despite the potential interest of these results, additional functional studies are still warranted to unravel the mechanisms by which these variants modulate the risk of AML. These findings suggested that IL13, VEGFA and IL8 SNPs play a role in modulating AML risk.
CitationBlood Cancer J. 2020 Jul 16;10(7):75. doi: 10.1038/s41408-020-00341-y.
AffiliationCiiM, Zentrum für individualisierte Infektionsmedizin, Feodor-Lynen-Str.7, 30625 Hannover.
JournalBlood cancer journal
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International
- Variations in genes involved in regulation of the nuclear factor - κB pathway and the risk of acute myeloid leukaemia.
- Authors: Rybka J, Gębura K, Wróbel T, Wysoczańska B, Stefanko E, Kuliczkowski K, Bogunia-Kubik K
- Issue date: 2016 Apr
- Clinical Implication of Toll-Like Receptors (TLR2 and TLR4) in Acute Myeloid Leukemia Patients.
- Authors: Aref S, Abd Elmaksoud ASM, Abd Elaziz S, Mabed M, Ayed M
- Issue date: 2020 Nov 1
- Polymorphisms in Host Immunity-Modulating Genes and Risk of Invasive Aspergillosis: Results from the AspBIOmics Consortium.
- Authors: Lupiañez CB, Canet LM, Carvalho A, Alcazar-Fuoli L, Springer J, Lackner M, Segura-Catena J, Comino A, Olmedo C, Ríos R, Fernández-Montoya A, Cuenca-Estrella M, Solano C, López-Nevot MÁ, Cunha C, Oliveira-Coelho A, Villaescusa T, Fianchi L, Aguado JM, Pagano L, López-Fernández E, Potenza L, Luppi M, Lass-Flörl C, Loeffler J, Einsele H, Vazquez L, PCRAGA Study Group, Jurado M, Sainz J
- Issue date: 2015 Dec 14
- CYP2B6 gene single nucleotide polymorphisms and leukemia susceptibility.
- Authors: Yuan ZH, Liu Q, Zhang Y, Liu HX, Zhao J, Zhu P
- Issue date: 2011 Mar
- Associations of interleukin-10 gene polymorphisms with acute myeloid leukemia in human (Egypt).
- Authors: Rashed R, Shafik RE, Shafik NF, Shafik HE
- Issue date: 2018 Jul-Sep