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dc.contributor.authorSandargo, Birthe
dc.contributor.authorJeske, Olga
dc.contributor.authorBoedeker, Christian
dc.contributor.authorWiegand, Sandra
dc.contributor.authorWennrich, Jan-Peer
dc.contributor.authorKallscheuer, Nicolai
dc.contributor.authorJogler, Mareike
dc.contributor.authorRohde, Manfred
dc.contributor.authorJogler, Christian
dc.contributor.authorSurup, Frank
dc.date.accessioned2020-11-19T11:03:08Z
dc.date.available2020-11-19T11:03:08Z
dc.date.issued2020-07-16
dc.identifier.citationFront Microbiol. 2020 Jul 16;11:1408. doi: 10.3389/fmicb.2020.01408.en_US
dc.identifier.issn1664-302X
dc.identifier.pmid32765432
dc.identifier.doi10.3389/fmicb.2020.01408
dc.identifier.urihttp://hdl.handle.net/10033/622597
dc.description.abstractBacteria of the phylum Planctomycetes occur ubiquitously in marine environments and play important roles in the marine nitrogen- and carbon cycle, for example as scavengers after phototrophic blooms. Here, we describe the isolation and characterization of the planctomycetal strain Enr13T isolated from a Posidonia sp. biofilm obtained from seawater sediment close to Panarea Island, Italy. Phylogenetic tree reconstruction based on 16S rRNA gene sequences and multi-locus sequence analysis supports the delineation of strain Enr13T from characterized species part of the phylum of Planctomycetes. HPLC-MS analysis of culture broth obtained from strain Enr13T revealed the presence of lipophilic metabolites, of which the major compound was isolated by preparative reversed-phase HPLC. The structure of this compound, named stieleriacine D (1), was elucidated utilizing HRESIMS, 1D- and 2D-NMR data as a new N-acylated dehydrotyrosine derivative. Its biosynthesis was proposed based on an in silico gene cluster analysis. Through analysis of the MS/MS spectrum of 1 and its minor derivative, stieleriacine E (2), it was possible to assign the structure of 2 without isolation. 1 showed antibacterial activity, however, the wide distribution of structurally related compounds indicates a potential role as a signaling molecule.en_US
dc.language.isoenen_US
dc.publisherFrontiersen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectantimicrobial activityen_US
dc.subjectbiofilmen_US
dc.subjectdehydroamino acidsen_US
dc.subjectplanctomycetesen_US
dc.subjectsecondary metabolitesen_US
dc.subjectsignalingen_US
dc.titleStieleriacines, N-Acyl Dehydrotyrosines From the Marine Planctomycete Stieleria neptunia sp. nov.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalFrontiers in microbiologyen_US
dc.source.volume11
dc.source.beginpage1408
dc.source.endpage
refterms.dateFOA2020-11-19T11:03:09Z
dc.source.journaltitleFrontiers in microbiology
dc.source.countrySwitzerland


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