Show simple item record

dc.contributor.authorKhailaie, Sahamoddin
dc.contributor.authorMontaseri, Ghazal
dc.contributor.authorMeyer-Hermann, Michael
dc.date.accessioned2020-11-25T10:28:57Z
dc.date.available2020-11-25T10:28:57Z
dc.date.issued2020-10-12
dc.identifier.citationiScience. 2020 Oct 12;23(11):101663. doi: 10.1016/j.isci.2020.101663.en_US
dc.identifier.pmid33134893
dc.identifier.doi10.1016/j.isci.2020.101663
dc.identifier.urihttp://hdl.handle.net/10033/622610
dc.description.abstractRegulatory T cells (Treg) are suppressor cells that control self-reactive and excessive effector conventional T helper cell (Tconv) responses. Breakdown of the balance between Tregs and Tconvs is a hallmark of autoimmune and inflammatory diseases. Interleukin-2 (IL-2) is a growth factor for both populations and subtle leverage to restore the healthy immune balance in IL-2 therapy. By using a mechanistic mathematical model, we introduced an adaptive control strategy to design the minimal therapeutic IL-2 dosage required to increase and stabilize Treg population and restrict inflammatory response. This adaptive protocol allows for dose adjustments based on the feedback of the immune kinetics of the patient. Our simulation results showed that a minimal Treg population was required to restrict the transient side effect of IL-2 injections on the effector Tconv response. In silico results suggested that a combination of IL-2 and adoptive Treg transfer therapies can limit this side effect.en_US
dc.language.isoenen_US
dc.publisherElsevier (Cell Press)en_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectBiological Sciencesen_US
dc.subjectImmunologyen_US
dc.subjectMathematical Bioscienceen_US
dc.titleAn Adaptive Control Scheme for Interleukin-2 Therapy.en_US
dc.typeArticleen_US
dc.identifier.eissn2589-0042
dc.contributor.departmentBRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56,38106 Braunschweig, Germany.en_US
dc.identifier.journaliScienceen_US
dc.source.volume23
dc.source.issue11
dc.source.beginpage101663
dc.source.endpage
refterms.dateFOA2020-11-25T10:28:58Z
dc.source.journaltitleiScience
dc.source.countryUnited States


Files in this item

Thumbnail
Name:
Publisher version
Thumbnail
Name:
Khailaie, Montaseri.,and Meyer ...
Size:
2.397Mb
Format:
PDF
Description:
Open Access article

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-ShareAlike 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International