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dc.contributor.authorMarcos-Torres, Francisco Javier
dc.contributor.authorVolz, Carsten
dc.contributor.authorMüller, Rolf
dc.date.accessioned2020-11-25T11:59:56Z
dc.date.available2020-11-25T11:59:56Z
dc.date.issued2020-11-04
dc.identifier.citationNat Commun. 2020 Nov 4;11(1):5563. doi: 10.1038/s41467-020-19384-7.en_US
dc.identifier.pmid33149152
dc.identifier.doi10.1038/s41467-020-19384-7
dc.identifier.urihttp://hdl.handle.net/10033/622611
dc.description.abstractStarvation induces cell aggregation in the soil bacterium Myxococcus xanthus, followed by formation of fruiting bodies packed with myxospores. Sporulation in the absence of fruiting bodies can be artificially induced by high concentrations of glycerol through unclear mechanisms. Here, we show that a compound (ambruticin VS-3) produced by a different myxobacterium, Sorangium cellulosum, affects the development of M. xanthus in a similar manner. Both glycerol (at millimolar levels) and ambruticin VS-3 (at nanomolar concentrations) inhibit M. xanthus fruiting body formation under starvation, and induce sporulation in the presence of nutrients. The response is mediated in M. xanthus by three hybrid histidine kinases (AskA, AskB, AskC) that form complexes interacting with two major developmental regulators (MrpC, FruA). In addition, AskB binds directly to the mrpC promoter in vitro. Thus, our work indicates that the AskABC-dependent regulatory pathway mediates the responses to ambruticin VS-3 and glycerol. We hypothesize that production of ambruticin VS-3 may allow S. sorangium to outcompete M. xanthus under both starvation and growth conditions in soil.en_US
dc.language.isoenen_US
dc.publisherNature Pulishing Groupen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleAn ambruticin-sensing complex modulates Myxococcus xanthus development and mediates myxobacterial interspecies communication.en_US
dc.typeArticleen_US
dc.identifier.eissn2041-1723
dc.contributor.departmentHIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.en_US
dc.identifier.journalNature communicationsen_US
dc.source.volume11
dc.source.issue1
dc.source.beginpage5563
dc.source.endpage
refterms.dateFOA2020-11-25T11:59:57Z
dc.source.journaltitleNature communications
dc.source.countryEngland


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International