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Authors
Anoumedem, Elodie Gisèle MMountessou, Bel Youssouf G
Kouam, Simeon F
Narmani, Abolfazl
Surup, Frank
Issue Date
2020-10-29
Metadata
Show full item recordAbstract
Two new tetracyclic polyketides with a spirocenter, simplicilones A (1) and B (2) were isolated from the broth-culture of the endophytic fungus Simplicilliumsubtropicum (SPC3) in the course of our screening for new bioactive secondary metabolites. This endophytoic fungus is naturally harboured in the fresh bark of the Cameroonian medicinal plant Duguetia staudtii (Engl. and Diels) Chatrou. The planar structures of the simplicilones were elucidated by MS and 1D as well as 2D NMR spectroscopic techniques. The relative configuration was assigned by NOESY experiments in conjunction with coupling constants; subsequently, the absolute configurations were assigned by the modified Mosher's method. The compounds showed weak cytotoxic effects against the cell line KB3.1 (in vitro cytotoxicity (IC50) = 25 µg/mL for 1, 29 µg/mL for 2), but were inactive against the tested Gram-positive and Gram-negative bacteria as well as fungi.Citation
Antibiotics (Basel). 2020 Oct 29;9(11):E753. doi: 10.3390/antibiotics9110753.Affiliation
HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.Publisher
MDPIJournal
Antibiotics (Basel, Switzerland)PubMed ID
33138149Type
ArticleLanguage
enISSN
2079-6382ae974a485f413a2113503eed53cd6c53
10.3390/antibiotics9110753
Scopus Count
The following license files are associated with this item:
- Creative Commons
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