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Issue Date
2020-10-20
Metadata
Show full item recordAbstract
Virus irradiation has been performed for many decades for basic research studies, sterilization, and vaccine development. The COVID-19 outbreak is currently causing an enormous effort worldwide for finding a vaccine against coronavirus. High doses of γ-rays can be used for the development of vaccines that exploit inactivated virus. This technique has been gradually replaced by more practical methods, in particular the use of chemicals, but irradiation remains a simple and effective method used in some cases. The technique employed for inactivating a virus has an impact on its ability to induce an adaptive immune response able to confer effective protection. We propose here that accelerated heavy ions can be used to inactivate SARS-CoV-2 viruses with small damage to the spike proteins of the envelope and can then provide an intact virion for vaccine development.Citation
Frontiers in Physics,(2020) 8 ;doi:10.3389/fphy.2020.565861.Affiliation
HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.Publisher
FrontiersJournal
Frontiers in PhysicsType
ReviewLanguage
enEISSN
2296424XSponsors
Horizon 2020ae974a485f413a2113503eed53cd6c53
10.3389/fphy.2020.565861
Scopus Count
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- Creative Commons