Attaching and effacing pathogens: the effector ABC of immune subversion.
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Issue Date
2020-07-27
Metadata
Show full item recordAbstract
The innate immune response resembles an essential barrier to bacterial infection. Many bacterial pathogens have, therefore, evolved mechanisms to evade from or subvert the host immune response in order to colonize, survive and multiply. The attaching and effacing pathogens enteropathogenic Escherichia coli, enterohaemorrhagic E. coli, Escherichia albertii and Citrobacter rodentium are Gram-negative extracellular gastrointestinal pathogens. They use a type III secretion system to inject effector proteins into the host cell to manipulate a variety of cellular processes. Over the last decade, considerable progress was made in identifying and characterizing the effector proteins of attaching and effacing pathogens that are involved in the inhibition of innate immune signaling pathways, in determining their host cell targets and elucidating the mechanisms they employ. Their functions will be reviewed here.Citation
Future Microbiol. 2020 Jul;15:945-958. doi: 10.2217/fmb-2019-0274. Epub 2020 Jul 27.Affiliation
BRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56,38106 Braunschweig, Germany.Publisher
Future Medicine Ltd.Journal
Future microbiologyPubMed ID
32716209Type
ReviewLanguage
enEISSN
1746-0921ae974a485f413a2113503eed53cd6c53
10.2217/fmb-2019-0274
Scopus Count
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- Creative Commons
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