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dc.contributor.authorRiebisch, Anna Katharina
dc.contributor.authorMühlen, Sabrina
dc.date.accessioned2020-12-01T10:08:25Z
dc.date.available2020-12-01T10:08:25Z
dc.date.issued2020-07-27
dc.identifier.citationFuture Microbiol. 2020 Jul;15:945-958. doi: 10.2217/fmb-2019-0274. Epub 2020 Jul 27.en_US
dc.identifier.pmid32716209
dc.identifier.doi10.2217/fmb-2019-0274
dc.identifier.urihttp://hdl.handle.net/10033/622625
dc.description.abstractThe innate immune response resembles an essential barrier to bacterial infection. Many bacterial pathogens have, therefore, evolved mechanisms to evade from or subvert the host immune response in order to colonize, survive and multiply. The attaching and effacing pathogens enteropathogenic Escherichia coli, enterohaemorrhagic E. coli, Escherichia albertii and Citrobacter rodentium are Gram-negative extracellular gastrointestinal pathogens. They use a type III secretion system to inject effector proteins into the host cell to manipulate a variety of cellular processes. Over the last decade, considerable progress was made in identifying and characterizing the effector proteins of attaching and effacing pathogens that are involved in the inhibition of innate immune signaling pathways, in determining their host cell targets and elucidating the mechanisms they employ. Their functions will be reviewed here.en_US
dc.language.isoenen_US
dc.publisherFuture Medicine Ltd.en_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectAE pathogensen_US
dc.subjectapoptosisen_US
dc.subjectinflammasomeen_US
dc.subjectinflammatory responseen_US
dc.subjectinnate immune responseen_US
dc.subjectnecroptosisen_US
dc.titleAttaching and effacing pathogens: the effector ABC of immune subversion.en_US
dc.typeReviewen_US
dc.identifier.eissn1746-0921
dc.contributor.departmentBRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56,38106 Braunschweig, Germany.en_US
dc.identifier.journalFuture microbiologyen_US
dc.source.volume15
dc.source.beginpage945
dc.source.endpage958
refterms.dateFOA2020-12-01T10:08:25Z
dc.source.journaltitleFuture microbiology
dc.source.countryEngland


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