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dc.contributor.authorLuo, Yi
dc.contributor.authorMöhn, Nora
dc.contributor.authorAl-Mekhlafi, Amani
dc.contributor.authorSchuchardt, Sven
dc.contributor.authorSkripuletz, Thomas
dc.contributor.authorSühs, Wolfram
dc.contributor.authorPessler, Frank
dc.contributor.authorStangel, Martin
dc.date.accessioned2020-12-11T14:38:57Z
dc.date.available2020-12-11T14:38:57Z
dc.date.issued2020-11-24
dc.identifier.citationPLoS One. 2020 Nov 24;15(11):e0242321. doi: 10.1371/journal.pone.0242321.en_US
dc.identifier.pmid33232337
dc.identifier.doi10.1371/journal.pone.0242321
dc.identifier.urihttp://hdl.handle.net/10033/622648
dc.description.abstractProgressive multifocal leukoencephalopathy (PML), caused by JC polyomavirus, is a demyelinating disease of the central nervous system that primarily affects oligodendrocytes. It can cause significant morbidity and mortality. An early diagnosis is of high relevance as timely immune reconstitution is essential. However, diagnosis can be challenging if virus detection via cerebrospinal fluid (CSF) PCR remains negative. Hence, identifying CSF biomarkers for this disease is of crucial importance. We applied a targeted metabolomic screen to CSF from 23 PML patients and eight normal pressure hydrocephalus (NPH) patients as controls. Out of 188 potentially detectable metabolites, 48 (13 amino acids, 4 biogenic amines, 1 acylcarnitine, 21 phosphatidylcholines, 8 sphingolipids, and the sum of hexoses) passed the quality screen and were included in the analyses. Even though there was a tendency towards lower concentrations in PML (mostly of phosphatidylcholines and sphingomyelins), none of the differences between PML and controls in individual metabolite concentrations reached statistical significance (lowest p = 0.104) and there were no potential diagnostic biomarkers (highest area under the ROC curve 0.68). Thus, CSF metabolite changes in PML are likely subtle and possibly larger group sizes and broader metabolite screens are needed to identify potential CSF metabolite biomarkers for PML.en_US
dc.language.isoenen_US
dc.publisherPLOSen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleTargeted metabolomic profiling of cerebrospinal fluid from patients with progressive multifocal leukoencephalopathy.en_US
dc.typeArticleen_US
dc.identifier.eissn1932-6203
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalPloS oneen_US
dc.source.volume15
dc.source.issue11
dc.source.beginpagee0242321
dc.source.endpage
refterms.dateFOA2020-12-11T14:38:58Z
dc.source.journaltitlePloS one
dc.source.countryUnited States


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International