Multi-omics examination of Q fever fatigue syndrome identifies similarities with chronic fatigue syndrome.
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Authors
Raijmakers, Ruud P HRoerink, Megan E
Jansen, Anne F M
Keijmel, Stephan P
Gacesa, Ranko
Li, Yang
Joosten, Leo A B
van der Meer, Jos W M
Netea, Mihai G
Bleeker-Rovers, Chantal P
Xu, Cheng-Jian
Issue Date
2020-11-26
Metadata
Show full item recordAbstract
Inflammatory markers, including 4E-BP1 (P = 9.60-16 and 1.41-7) and MMP-1 (P = 7.09-9 and 3.51-9), are significantly more expressed in both QFS and CFS patients compared to HC. Blood metabolite profiles show significant differences when comparing QFS (319 metabolites) and CFS (441 metabolites) patients to HC, and are significantly enriched in pathways like sphingolipid (P = 0.0256 and 0.0033) metabolism. When comparing QFS to CFS patients, almost no significant differences in metabolome were found. Comparison of microbiome taxonomy of QFS and CFS patients with that of HC, shows both in- and decreases in abundancies in Bacteroidetes (with emphasis on Bacteroides and Alistiples spp.), and Firmicutes and Actinobacteria (with emphasis on Ruminococcus and Bifidobacterium spp.). When we compare QFS patients to CFS patients, there is a striking resemblance and hardly any significant differences in microbiome taxonomy are found.Citation
J Transl Med. 2020 Nov 26;18(1):448. doi: 10.1186/s12967-020-02585-5.Affiliation
HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.Publisher
BMCPubMed ID
33243243Type
ArticleLanguage
enEISSN
1479-5876ae974a485f413a2113503eed53cd6c53
10.1186/s12967-020-02585-5
Scopus Count
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- Creative Commons