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dc.contributor.authorVehmeijer, Florianne O L
dc.contributor.authorKüpers, Leanne K
dc.contributor.authorSharp, Gemma C
dc.contributor.authorSalas, Lucas A
dc.contributor.authorLent, Samantha
dc.contributor.authorJima, Dereje D
dc.contributor.authorTindula, Gwen
dc.contributor.authorReese, Sarah
dc.contributor.authorQi, Cancan
dc.contributor.authorGruzieva, Olena
dc.contributor.authorPage, Christian
dc.contributor.authorRezwan, Faisal I
dc.contributor.authorMelton, Philip E
dc.contributor.authorNohr, Ellen
dc.contributor.authorEscaramís, Geòrgia
dc.contributor.authorRzehak, Peter
dc.contributor.authorHeiskala, Anni
dc.contributor.authorGong, Tong
dc.contributor.authorTuominen, Samuli T
dc.contributor.authorGao, Lu
dc.contributor.authorRoss, Jason P
dc.contributor.authorStarling, Anne P
dc.contributor.authorHolloway, John W
dc.contributor.authorYousefi, Paul
dc.contributor.authorAasvang, Gunn Marit
dc.contributor.authorBeilin, Lawrence J
dc.contributor.authorBergström, Anna
dc.contributor.authorBinder, Elisabeth
dc.contributor.authorChatzi, Leda
dc.contributor.authorCorpeleijn, Eva
dc.contributor.authorCzamara, Darina
dc.contributor.authorEskenazi, Brenda
dc.contributor.authorEwart, Susan
dc.contributor.authorFerre, Natalia
dc.contributor.authorGrote, Veit
dc.contributor.authorGruszfeld, Dariusz
dc.contributor.authorHåberg, Siri E
dc.contributor.authorHoyo, Cathrine
dc.contributor.authorHuen, Karen
dc.contributor.authorKarlsson, Robert
dc.contributor.authorKull, Inger
dc.contributor.authorLanghendries, Jean-Paul
dc.contributor.authorLepeule, Johanna
dc.contributor.authorMagnus, Maria C
dc.contributor.authorMaguire, Rachel L
dc.contributor.authorMolloy, Peter L
dc.contributor.authorMonnereau, Claire
dc.contributor.authorMori, Trevor A
dc.contributor.authorOken, Emily
dc.contributor.authorRäikkönen, Katri
dc.contributor.authorRifas-Shiman, Sheryl
dc.contributor.authorRuiz-Arenas, Carlos
dc.contributor.authorSebert, Sylvain
dc.contributor.authorUllemar, Vilhelmina
dc.contributor.authorVerduci, Elvira
dc.contributor.authorVonk, Judith M
dc.contributor.authorXu, Cheng-Jian
dc.contributor.authorYang, Ivana V
dc.contributor.authorZhang, Hongmei
dc.contributor.authorZhang, Weiming
dc.contributor.authorKarmaus, Wilfried
dc.contributor.authorDabelea, Dana
dc.contributor.authorMuhlhausler, Beverly S
dc.contributor.authorBreton, Carrie V
dc.contributor.authorLahti, Jari
dc.contributor.authorAlmqvist, Catarina
dc.contributor.authorJarvelin, Marjo-Riitta
dc.contributor.authorKoletzko, Berthold
dc.contributor.authorVrijheid, Martine
dc.contributor.authorSørensen, Thorkild I A
dc.contributor.authorHuang, Rae-Chi
dc.contributor.authorArshad, Syed Hasan
dc.contributor.authorNystad, Wenche
dc.contributor.authorMelén, Erik
dc.contributor.authorKoppelman, Gerard H
dc.contributor.authorLondon, Stephanie J
dc.contributor.authorHolland, Nina
dc.contributor.authorBustamante, Mariona
dc.contributor.authorMurphy, Susan K
dc.contributor.authorHivert, Marie-France
dc.contributor.authorBaccarelli, Andrea
dc.contributor.authorRelton, Caroline L
dc.contributor.authorSnieder, Harold
dc.contributor.authorJaddoe, Vincent W V
dc.contributor.authorFelix, Janine F
dc.date.accessioned2020-12-14T14:36:05Z
dc.date.available2020-12-14T14:36:05Z
dc.date.issued2020-11-25
dc.identifier.citationGenome Med. 2020 Nov 25;12(1):105. doi: 10.1186/s13073-020-00810-w.en_US
dc.identifier.pmid33239103
dc.identifier.doi10.1186/s13073-020-00810-w
dc.identifier.urihttp://hdl.handle.net/10033/622651
dc.description.abstractDNA methylation at three CpGs (cg05937453, cg25212453, and cg10040131), each in a different age range, was associated with BMI at Bonferroni significance, P < 1.06 × 10-7, with a 0.96 standard deviation score (SDS) (standard error (SE) 0.17), 0.32 SDS (SE 0.06), and 0.32 BMI SDS (SE 0.06) higher BMI per 10% increase in methylation, respectively. DNA methylation at nine additional CpGs in the cross-sectional childhood model was associated with BMI at false discovery rate significance. The strength of the associations of DNA methylation at the 187 CpGs previously identified to be associated with adult BMI, increased with advancing age across childhood and adolescence in our analyses. In addition, correlation coefficients between effect estimates for those CpGs in adults and in children and adolescents also increased. Among the top findings for each age range, we observed increasing enrichment for the CpGs that were previously identified in adults (birth Penrichment = 1; childhood Penrichment = 2.00 × 10-4; adolescence Penrichment = 2.10 × 10-7).en_US
dc.language.isoenen_US
dc.publisherBMCen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectBody mass indexen_US
dc.subjectChildhood obesityen_US
dc.subjectDNA methylationen_US
dc.subjectEpigeneticsen_US
dc.titleDNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies.en_US
dc.typeArticleen_US
dc.identifier.eissn1756-994X
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalGenome medicineen_US
dc.source.volume12
dc.source.issue1
dc.source.beginpage105
dc.source.endpage
refterms.dateFOA2020-12-14T14:36:05Z
dc.source.journaltitleGenome medicine
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryEngland


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