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dc.contributor.authorWu, Qingyu
dc.contributor.authorJorde, Ilka
dc.contributor.authorKershaw, Olivia
dc.contributor.authorJeron, Andreas
dc.contributor.authorBruder, Dunja
dc.contributor.authorSchreiber, Jens
dc.contributor.authorStegemann-Koniszewski, Sabine
dc.date.accessioned2021-01-05T13:01:26Z
dc.date.available2021-01-05T13:01:26Z
dc.date.issued2020-11-27
dc.identifier.citationMicroorganisms. 2020 Nov 27;8(12):1878. doi: 10.3390/microorganisms8121878.en_US
dc.identifier.issn2076-2607
dc.identifier.pmid33260910
dc.identifier.doi10.3390/microorganisms8121878
dc.identifier.urihttp://hdl.handle.net/10033/622661
dc.description.abstractAllergic airway inflammation (AAI) involves T helper cell type 2 (Th2) and pro-inflammatory responses to aeroallergens and many predisposing factors remain elusive. Influenza A virus (IAV) is a major human pathogen that causes acute respiratory infections and induces specific immune responses essential for viral clearance and resolution of the infection. Beyond acute infection, IAV has been shown to persistently affect lung homeostasis and respiratory immunity. Here we asked how resolved IAV infection affects subsequently induced AAI. Mice infected with a sublethal dose of IAV were sensitized and challenged in an ovalbumin mediated mouse model for AAI after resolution of the acute viral infection. Histological changes, respiratory leukocytes, cytokines and airway hyperreactivity were analyzed in resolved IAV infection alone and in AAI with and without previous IAV infection. More than five weeks after infection, we detected persistent pneumonia with increased activated CD4+ and CD8+ lymphocytes as well as dendritic cells and MHCII expressing macrophages in the lung. Resolved IAV infection significantly affected subsequently induced AAI on different levels including morphological changes, respiratory leukocytes and lymphocytes as well as the pro-inflammatory cytokine responses, which was clearly diminished. We conclude that IAV has exceptional persisting effects on respiratory immunity with substantial consequences for subsequently induced AAI.en_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectallergic airway inflammationen_US
dc.subjectallergic asthmaen_US
dc.subjectinfluenza A virusen_US
dc.subjectmacrophagesen_US
dc.subjectpro-inflammatory cytokinesen_US
dc.subjectrespiratory immune regulationen_US
dc.titleResolved Influenza A Virus Infection Has Extended Effects on Lung Homeostasis and Attenuates Allergic Airway Inflammation in a Mouse Model.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalMicroorganismsen_US
dc.source.volume8
dc.source.issue12
refterms.dateFOA2021-01-05T13:01:27Z
dc.source.journaltitleMicroorganisms
dc.source.countrySwitzerland


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International