Total Synthesis and Structure Revision of Halioxepine.

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Authors
Poock, Caroline
Kalesse, Markus cc
Issue Date
2020-11-20

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Abstract
The first total synthesis of halioxepine is accomplished using a 1,4-addition for constructing the quaternary center at C10 and a halo etherification for the generation of the tertiary ether at C7. The correct structure of halioxepine was determined by assembling different enantiomeric building blocks and by changing the relative configuration between C10 and C15.
Citation
Chemistry. 2020 Nov 20. doi: 10.1002/chem.202004847.
Affiliation
HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.
Publisher
Wiley
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
URI
http://hdl.handle.net/10033/622672
DOI
10.1002/chem.202004847
PubMed ID
33215739
Type
Article
Language
en
EISSN
1521-3765
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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International