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dc.contributor.authorBarua, Arnab
dc.contributor.authorNava-Sedeño, Josue M
dc.contributor.authorMeyer-Hermann, Michael
dc.contributor.authorHatzikirou, Haralampos
dc.date.accessioned2021-01-14T12:59:00Z
dc.date.available2021-01-14T12:59:00Z
dc.date.issued2020-12-22
dc.identifier.citationSci Rep. 2020 Dec 22;10(1):22371. doi: 10.1038/s41598-020-79119-y.en_US
dc.identifier.pmid33353977
dc.identifier.doi10.1038/s41598-020-79119-y
dc.identifier.urihttp://hdl.handle.net/10033/622680
dc.description.abstractCollective migration is commonly observed in groups of migrating cells, in the form of swarms or aggregates. Mechanistic models have proven very useful in understanding collective cell migration. Such models, either explicitly consider the forces involved in the interaction and movement of individuals or phenomenologically define rules which mimic the observed behavior of cells. However, mechanisms leading to collective migration are varied and specific to the type of cells involved. Additionally, the precise and complete dynamics of many important chemomechanical factors influencing cell movement, from signalling pathways to substrate sensing, are typically either too complex or largely unknown. The question is how to make quantitative/qualitative predictions of collective behavior without exact mechanistic knowledge. Here we propose the least microenvironmental uncertainty principle (LEUP) that may serve as a generative model of collective migration without precise incorporation of full mechanistic details. Using statistical physics tools, we show that the famous Vicsek model is a special case of LEUP. Finally, to test the biological applicability of our theory, we apply LEUP to construct a model of the collective behavior of spherical Serratia marcescens bacteria, where the underlying migration mechanisms remain elusive.en_US
dc.language.isoenen_US
dc.publisherNature researchen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleA least microenvironmental uncertainty principle (LEUP) as a generative model of collective cell migration mechanisms.en_US
dc.typeArticleen_US
dc.identifier.eissn2045-2322
dc.contributor.departmentBRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56,38106 Braunschweig, Germany.en_US
dc.identifier.journalScientific reportsen_US
dc.source.volume10
dc.source.issue1
dc.source.beginpage22371
dc.source.endpage
refterms.dateFOA2021-01-14T12:59:01Z
dc.source.journaltitleScientific reports
dc.source.countryEngland


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International