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dc.contributor.authorHering, Stefanie
dc.contributor.authorSchäuble, Nico
dc.contributor.authorBuck, Thomas M.
dc.contributor.authorLoretz, Brigitta
dc.contributor.authorRillmann, Thomas
dc.contributor.authorStieneker, Frank
dc.contributor.authorLehr, Claus Michael
dc.date.accessioned2021-01-26T14:43:06Z
dc.date.available2021-01-26T14:43:06Z
dc.date.issued2021-01-01
dc.identifier.citationHERING, Stefanie, et al. Analysis and Optimization of Two Film-Coated Tablet Production Processes by Computer Simulation: A Case Study. Processes, 2021, 9. Jg., Nr. 1, S. 67.en_US
dc.identifier.doi10.3390/pr9010067
dc.identifier.urihttp://hdl.handle.net/10033/622701
dc.description.abstractIncreasing regulatory demands are forcing the pharmaceutical industry to invest its available resources carefully. This is especially challenging for small- and middle-sized companies. Computer simulation software like FlexSim allows one to explore variations in production processes without the need to interrupt the running process. Here, we applied a discrete-event simulation to two approved film-coated tablet production processes. The simulations were performed with FlexSim (FlexSim Deutschland—Ingenieurbüro für Simulationsdienstleistung Ralf Gruber, Kirchlengern, Germany). Process visualization was done using Cmap Tools (Florida Institute for Human and Machine Cognition, Pensacola, FL, USA), and statistical analysis used MiniTab® (Minitab GmbH, Munich, Germany). The most critical elements identified during model building were the model logic, operating schedule, and processing times. These factors were graphically and statistically verified. To optimize the utilization of employees, three different shift systems were simulated, thereby revealing the advantages of two-shift and one-and-a-half-shift systems compared to a one-shift system. Without the need to interrupt any currently running production processes, we found that changing the shift system could save 50–53% of the campaign duration and 9–14% of the labor costs. In summary, we demonstrated that FlexSim, which is mainly used in logistics, can also be advantageously implemented for modeling and optimizing pharmaceutical production processes.en_US
dc.description.sponsorshipDeutsche Forschungsgemeinschaften_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject3D simulation modeling and analysisen_US
dc.subjectBottleneck analysisen_US
dc.subjectModel implementationen_US
dc.subjectProduction costsen_US
dc.subjectResource conservationen_US
dc.titleAnalysis and optimization of two film-coated tablet production processes by computer simulation: A case studyen_US
dc.typeArticleen_US
dc.identifier.eissn22279717
dc.contributor.departmentHIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.en_US
dc.identifier.journalProcessesen_US
dc.identifier.eid2-s2.0-85098872880
dc.identifier.scopusidSCOPUS_ID:85098872880
dc.source.volume9
dc.source.issue1
dc.source.beginpage1
dc.source.endpage18
refterms.dateFOA2021-01-26T14:43:06Z
dc.source.journaltitleProcesses


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Except where otherwise noted, this item's license is described as Attribution 4.0 International