Redispersible Spray-Dried Powder Containing Nanoencapsulated Curcumin: the Drying Process Does Not Affect Neuroprotection In vitro.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authorsde Andrade, Diego Fontana
Hoppe, Juliana Bender
Pohlmann, Adriana Raffin
Guterres, Sílvia Stanisçuaski
Salbego, Christianne Gazzana
Beck, Ruy Carlos Ruver
MetadataShow full item record
AbstractA redispersible spray-dried formulation containing curcumin-loaded, lipid-core nanocapsules (LNC-C) was developed for oral administration. The neuroprotective activity of curcumin after the spray-drying process was evaluated in vitro. The spray-dried powder (SD-LNC-C) was produced using a drying adjuvant composed of a blend of maltodextrin and L-leucine (90:10 w/w). Acceptable process yield (~ 70%) and drug content (6.5 ± 0.2 mg g-1) were obtained. SD-LNC-C was formed by smooth, spherical-shaped particles, and confocal Raman analysis indicated the distribution of the LNC-C on the surface of the leucine/maltodextrin agglomerates. The surface of the agglomerates was formed by a combination of LNC-C and adjuvants, and laser diffraction showed that SD-LNC-C had adequate aqueous redispersion, with no loss of controlled drug release behaviour of LNC-C. The in vitro curcumin activity against the lipopolysaccharide (LPS)-induced proinflammatory response in organotypic hippocampal slice cultures was evaluated. Both formulations (LNC-C and SD-LNC-C) reduced TNF-α to similar levels. Therefore, neuroprotection of curcumin in vitro may be improved by nanoencapsulation followed by spray-drying, with no loss of this superior performance. Hence, the redispersible spray-dried powder proposed here represents a suitable approach for the development of innovative nanomedicines containing curcumin for the prevention/treatment of neurodegenerative diseases.
CitationAAPS PharmSciTech. 2019 Aug 12;20(7):283. doi: 10.1208/s12249-019-1501-1.
AffiliationHIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.;TWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH,Feodor-Lynen Str. 7, 30625 Hannover, Germany.
The following license files are associated with this item:
- Creative Commons
- Redispersible spray-dried lipid-core nanocapsules intended for oral delivery: the influence of the particle number on redispersibility.
- Authors: Andrade DF, Vukosavljevic B, Benvenutti EV, Pohlmann AR, Guterres SS, Windbergs M, Beck RCR
- Issue date: 2018 Apr
- Reconstituted spray-dried phenytoin-loaded nanocapsules improve the in vivo phenytoin anticonvulsant effect and the survival time in mice.
- Authors: de Oliveira EG, Cardoso AM, Paese K, Coradini K, de Oliveira CV, Pohlmann AR, Oliveira MS, Guterres SS, Beck RCR
- Issue date: 2018 Nov 15
- Presence of electrostatically adsorbed polysaccharides improves spray drying of liposomes.
- Authors: Karadag A, Özçelik B, Sramek M, Gibis M, Kohlus R, Weiss J
- Issue date: 2013 Feb
- Hydrogels containing redispersible spray-dried melatonin-loaded nanocapsules: a formulation for transdermal-controlled delivery.
- Authors: Hoffmeister CR, Durli TL, Schaffazick SR, Raffin RP, Bender EA, Beck RC, Pohlmann AR, Guterres SS
- Issue date: 2012 May 15
- Redispersible liposomal-N-acetylcysteine powder for pulmonary administration: development, in vitro characterization and antioxidant activity.
- Authors: Ourique AF, Chaves Pdos S, Souto GD, Pohlmann AR, Guterres SS, Beck RC
- Issue date: 2014 Dec 18