Contact-dependent transmission of Langat and tick-borne encephalitis virus in type I interferon receptor-1 deficient mice.
Schreier, Cebulski and Kröger.pdf
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractTick-borne encephalitis virus (TBEV) is primarily transmitted to humans through tick bites or oral consumption of accordingly contaminated unpasteurized milk or milk products. The detection of TBEV RNA in various body fluids in immunosuppressed human patients is documented. However, the risk of direct contact exposure remains unclear. Interferon-alpha receptor-1 deficient (Ifnar1-/- ) mice, which are lacking the interferon-α/β responses, develop neurologic manifestations after infection with TBEV and Langat virus (LGTV). We showed that subcutaneous, intranasal, and peroral infection of LGTV lead to disease, whereas mice with intragastric application of LGTV showed no disease signs. With LGTV infected mice exhibit seroconversion and significant viral RNA levels was detected in saliva, eye smear, feces and urine. As a result, TBEV and LGTV are transmitted between mice from infected to naïve co-caged sentinel animals. Although intranasal inoculation of LGTV is entirely sufficient to establish the disease in mice, the virus is not transmitted by aerosols. These pooled results from animal models highlight the risks of exposure to TBEV contaminants and the possibility for close contact transmission of TBEV in interferon-alpha receptor-1 deficient laboratory mice.Importance Tick-borne encephalitis is a severe disease of the central nervous system caused by the tick-borne encephalitis virus (TBEV). Every year between 10,000-12,000 people become infected with this flavivirus. The TBEV is usually transmitted to humans via the bite of a tick, but infections due to consumption of infectious milk products are increasingly being reported. Since there is no therapy for an TBEV infection and mechanisms of virus persistence in reservoir animals are unclear, it is important to highlight the risk of exposure to TBEV contaminants and know possible routes of transmission of this virus. The significance of our research is in identifying other infection routes of TBEV and LGTV, and the possibility of close contact transmission.
CitationJ Virol. 2021 Jan 27:JVI.02039-20. doi: 10.1128/JVI.02039-20. Epub ahead of print.
AffiliationHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.
PublisherAmerican Society for Microbiology
JournalJournal of virology
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International
- Type I interferon protects mice from fatal neurotropic infection with Langat virus by systemic and local antiviral responses.
- Authors: Weber E, Finsterbusch K, Lindquist R, Nair S, Lienenklaus S, Gekara NO, Janik D, Weiss S, Kalinke U, Överby AK, Kröger A
- Issue date: 2014 Nov
- Cross-reactive antibodies against Langat virus protect mice from lethal tick-borne encephalitis virus infection.
- Authors: Kubinski M, Beicht J, Zdora I, Saletti G, Kircher M, Petry-Gusmag M, Steffen I, Puff C, Jung K, Baumgärtner W, Rimmelzwaan GF, Osterhaus ADME, Prajeeth CK
- Issue date: 2023
- Comparison of Extraction Methods for the Detection of Tick-Borne Encephalitis Virus RNA in Goat Raw Milk and Cream Cheese.
- Authors: Müller I, Althof N, Hoffmann B, Klaus C, Schilling-Loeffler K, Falkenhagen A, Johne R
- Issue date: 2023 Mar
- MicroRNA-based control of tick-borne flavivirus neuropathogenesis: Challenges and perspectives.
- Authors: Teterina NL, Maximova OA, Kenney H, Liu G, Pletnev AG
- Issue date: 2016 Mar
- A tick-borne encephalitis model in infant rats infected with langat virus.
- Authors: Maffioli C, Grandgirard D, Engler O, Leib SL
- Issue date: 2014 Dec