The transplant cohort of the German center for infection research (DZIF Tx-Cohort): study design and baseline characteristics.
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Authors
Karch, AndréSchindler, Daniela
Kühn-Steven, Andrea
Blaser, Rainer
Kuhn, Klaus A
Sandmann, Lisa
Sommerer, Claudia
Guba, Markus
Heemann, Uwe
Strohäker, Jens
Glöckner, Stephan
Mikolajczyk, Rafael
Busch, Dirk H
Schulz, Thomas F
Issue Date
2021-01-25
Metadata
Show full item recordAbstract
Infectious complications are the major cause of morbidity and mortality after solid organ and stem cell transplantation. To better understand host and environmental factors associated with an increased risk of infection as well as the effect of infections on function and survival of transplanted organs, we established the DZIF Transplant Cohort, a multicentre prospective cohort study within the organizational structure of the German Center for Infection Research. At time of transplantation, heart-, kidney-, lung-, liver-, pancreas- and hematopoetic stem cell- transplanted patients are enrolled into the study. Follow-up visits are scheduled at 3, 6, 9, 12 months after transplantation, and annually thereafter; extracurricular visits are conducted in case of infectious complications. Comprehensive standard operating procedures, web-based data collection and monitoring tools as well as a state of the art biobanking concept for blood, purified PBMCs, urine, and faeces samples ensure high quality of data and biosample collection. By collecting detailed information on immunosuppressive medication, infectious complications, type of infectious agent and therapy, as well as by providing corresponding biosamples, the cohort will establish the foundation for a broad spectrum of studies in the field of infectious diseases and transplant medicine. By January 2020, baseline data and biosamples of about 1400 patients have been collected. We plan to recruit 3500 patients by 2023, and continue follow-up visits and the documentation of infectious events at least until 2025. Information about the DZIF Transplant Cohort is available at https://www.dzif.de/en/working-group/transplant-cohort .Citation
Eur J Epidemiol. 2021 Jan 25. doi: 10.1007/s10654-020-00715-3. Epub ahead of print.Affiliation
HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.Publisher
SpringerJournal
European journal of epidemiologyPubMed ID
33492549Type
ArticleLanguage
enEISSN
1573-7284ae974a485f413a2113503eed53cd6c53
10.1007/s10654-020-00715-3
Scopus Count
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