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dc.contributor.authorChumduri, Cindrilla
dc.contributor.authorGurumurthy, Rajendra Kumar
dc.contributor.authorBerger, Hilmar
dc.contributor.authorDietrich, Oliver
dc.contributor.authorKumar, Naveen
dc.contributor.authorKoster, Stefanie
dc.contributor.authorBrinkmann, Volker
dc.contributor.authorHoffmann, Kirstin
dc.contributor.authorDrabkina, Marina
dc.contributor.authorArampatzi, Panagiota
dc.contributor.authorSon, Dajung
dc.contributor.authorKlemm, Uwe
dc.contributor.authorMollenkopf, Hans-Joachim
dc.contributor.authorHerbst, Hermann
dc.contributor.authorMangler, Mandy
dc.contributor.authorVogel, Jörg
dc.contributor.authorSaliba, Antoine-Emmanuel
dc.contributor.authorMeyer, Thomas F
dc.date.accessioned2021-02-16T13:51:59Z
dc.date.available2021-02-16T13:51:59Z
dc.date.issued2021-01-18
dc.identifier.citationNat Cell Biol. 2021 Feb;23(2):184-197. doi: 10.1038/s41556-020-00619-0. Epub 2021 Jan 18.en_US
dc.identifier.pmid33462395
dc.identifier.doi10.1038/s41556-020-00619-0
dc.identifier.urihttp://hdl.handle.net/10033/622746
dc.description.abstractThe transition zones of the squamous and columnar epithelia constitute hotspots for the emergence of cancer, often preceded by metaplasia, in which one epithelial type is replaced by another. It remains unclear how the epithelial spatial organization is maintained and how the transition zone niche is remodelled during metaplasia. Here we used single-cell RNA sequencing to characterize epithelial subpopulations and the underlying stromal compartment of endo- and ectocervix, encompassing the transition zone. Mouse lineage tracing, organoid culture and single-molecule RNA in situ hybridizations revealed that the two epithelia derive from separate cervix-resident lineage-specific stem cell populations regulated by opposing Wnt signals from the stroma. Using a mouse model of cervical metaplasia, we further show that the endocervical stroma undergoes remodelling and increases expression of the Wnt inhibitor Dickkopf-2 (DKK2), promoting the outgrowth of ectocervical stem cells. Our data indicate that homeostasis at the transition zone results from divergent stromal signals, driving the differential proliferation of resident epithelial lineages.en_US
dc.language.isoenen_US
dc.publisherNature researchen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleOpposing Wnt signals regulate cervical squamocolumnar homeostasis and emergence of metaplasia.en_US
dc.typeArticleen_US
dc.identifier.eissn1476-4679
dc.contributor.departmentHIRI, Helmholtz-Institut für RNA-basierte Infektionsforschung, Josef-Shneider Strasse 2, 97080 Würzburg, Germany.en_US
dc.identifier.journalNature cell biologyen_US
dc.source.volume23
dc.source.issue2
dc.source.beginpage184
dc.source.endpage197
refterms.dateFOA2021-02-16T13:52:00Z
dc.source.journaltitleNature cell biology
dc.source.countryEngland


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International