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dc.contributor.authorAhmetlić, Fatima
dc.contributor.authorRiedel, Tanja
dc.contributor.authorHömberg, Nadine
dc.contributor.authorBauer, Vera
dc.contributor.authorTrautwein, Nico
dc.contributor.authorGeishauser, Albert
dc.contributor.authorSparwasser, Tim
dc.contributor.authorStevanović, Stefan
dc.contributor.authorRöcken, Martin
dc.contributor.authorMocikat, Ralph
dc.date.accessioned2021-03-03T15:34:07Z
dc.date.available2021-03-03T15:34:07Z
dc.date.issued2019-03-20
dc.identifier.citationCancer Immunol Res. 2019 Apr;7(4):600-608. doi: 10.1158/2326-6066.CIR-18-0419. Epub 2019 Mar 20.en_US
dc.identifier.pmid30894379
dc.identifier.doi10.1158/2326-6066.CIR-18-0419
dc.identifier.urihttp://hdl.handle.net/10033/622766
dc.description.abstractFoxp3+ regulatory T cells (Tregs) sustain immune homeostasis and may contribute to immune escape in malignant disease. As a prerequisite for developing immunologic approaches in cancer therapy, it is necessary to understand the ontogeny and the antigenic specificities of tumor-infiltrating Tregs. We addressed this question by using a λ-MYC transgenic mouse model of endogenously arising B-cell lymphoma, which mirrors key features of human Burkitt lymphoma. We show that Foxp3+ Tregs suppress antitumor responses in endogenous lymphoma. Ablation of Foxp3+ Tregs significantly delayed tumor development. The ratio of Treg to effector T cells was elevated in growing tumors, which could be ascribed to differential proliferation. The Tregs detected were mainly natural Tregs that apparently recognized self-antigens. We identified MHC class II-restricted nonmutated self-epitopes, which were more prevalent in lymphoma than in normal B cells and could be recognized by Tregs. These epitopes were derived from proteins that are associated with cellular processes related to malignancy and may be overexpressed in the tumor.en_US
dc.language.isoenen_US
dc.publisherAmerican Association for Cancer Research (AACR)en_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleRegulatory T Cells in an Endogenous Mouse Lymphoma Recognize Specific Antigen Peptides and Contribute to Immune Escape.en_US
dc.typeArticleen_US
dc.identifier.eissn2326-6074
dc.contributor.departmentTWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH,Feodor-Lynen Str. 7, 30625 Hannover, Germany.en_US
dc.identifier.journalCancer immunology researchen_US
dc.source.volume7
dc.source.issue4
dc.source.beginpage600
dc.source.endpage608
refterms.dateFOA2021-03-03T15:34:08Z
dc.source.journaltitleCancer immunology research
dc.source.countryUnited States


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