Regulatory T Cells in an Endogenous Mouse Lymphoma Recognize Specific Antigen Peptides and Contribute to Immune Escape.
dc.contributor.author | Ahmetlić, Fatima | |
dc.contributor.author | Riedel, Tanja | |
dc.contributor.author | Hömberg, Nadine | |
dc.contributor.author | Bauer, Vera | |
dc.contributor.author | Trautwein, Nico | |
dc.contributor.author | Geishauser, Albert | |
dc.contributor.author | Sparwasser, Tim | |
dc.contributor.author | Stevanović, Stefan | |
dc.contributor.author | Röcken, Martin | |
dc.contributor.author | Mocikat, Ralph | |
dc.date.accessioned | 2021-03-03T15:34:07Z | |
dc.date.available | 2021-03-03T15:34:07Z | |
dc.date.issued | 2019-03-20 | |
dc.identifier.citation | Cancer Immunol Res. 2019 Apr;7(4):600-608. doi: 10.1158/2326-6066.CIR-18-0419. Epub 2019 Mar 20. | en_US |
dc.identifier.pmid | 30894379 | |
dc.identifier.doi | 10.1158/2326-6066.CIR-18-0419 | |
dc.identifier.uri | http://hdl.handle.net/10033/622766 | |
dc.description.abstract | Foxp3+ regulatory T cells (Tregs) sustain immune homeostasis and may contribute to immune escape in malignant disease. As a prerequisite for developing immunologic approaches in cancer therapy, it is necessary to understand the ontogeny and the antigenic specificities of tumor-infiltrating Tregs. We addressed this question by using a λ-MYC transgenic mouse model of endogenously arising B-cell lymphoma, which mirrors key features of human Burkitt lymphoma. We show that Foxp3+ Tregs suppress antitumor responses in endogenous lymphoma. Ablation of Foxp3+ Tregs significantly delayed tumor development. The ratio of Treg to effector T cells was elevated in growing tumors, which could be ascribed to differential proliferation. The Tregs detected were mainly natural Tregs that apparently recognized self-antigens. We identified MHC class II-restricted nonmutated self-epitopes, which were more prevalent in lymphoma than in normal B cells and could be recognized by Tregs. These epitopes were derived from proteins that are associated with cellular processes related to malignancy and may be overexpressed in the tumor. | en_US |
dc.language.iso | en | en_US |
dc.publisher | American Association for Cancer Research (AACR) | en_US |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.title | Regulatory T Cells in an Endogenous Mouse Lymphoma Recognize Specific Antigen Peptides and Contribute to Immune Escape. | en_US |
dc.type | Article | en_US |
dc.identifier.eissn | 2326-6074 | |
dc.contributor.department | TWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH,Feodor-Lynen Str. 7, 30625 Hannover, Germany. | en_US |
dc.identifier.journal | Cancer immunology research | en_US |
dc.source.volume | 7 | |
dc.source.issue | 4 | |
dc.source.beginpage | 600 | |
dc.source.endpage | 608 | |
refterms.dateFOA | 2021-03-03T15:34:08Z | |
dc.source.journaltitle | Cancer immunology research | |
dc.source.country | United States |