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dc.contributor.authorAtanasov, Atanas G
dc.contributor.authorZotchev, Sergey B
dc.contributor.authorDirsch, Verena M
dc.contributor.authorSupuran, Claudiu T
dc.date.accessioned2021-03-04T12:56:57Z
dc.date.available2021-03-04T12:56:57Z
dc.date.issued2021-01-28
dc.identifier.citationNat Rev Drug Discov. 2021 Jan 28:1–17. doi: 10.1038/s41573-020-00114-z. Epub ahead of print.en_US
dc.identifier.pmid33510482
dc.identifier.doi10.1038/s41573-020-00114-z
dc.identifier.urihttp://hdl.handle.net/10033/622770
dc.description.abstractNatural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural products also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization, which contributed to a decline in their pursuit by the pharmaceutical industry from the 1990s onwards. In recent years, several technological and scientific developments - including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances - are addressing such challenges and opening up new opportunities. Consequently, interest in natural products as drug leads is being revitalized, particularly for tackling antimicrobial resistance. Here, we summarize recent technological developments that are enabling natural product-based drug discovery, highlight selected applications and discuss key opportunities.en_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleNatural products in drug discovery: advances and opportunities.en_US
dc.typeReviewen_US
dc.identifier.eissn1474-1784
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.; HIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.en_US
dc.identifier.journalNature reviews. Drug discoveryen_US
refterms.dateFOA2021-03-04T12:56:58Z
dc.source.journaltitleNature reviews. Drug discovery
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryEngland


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International