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dc.contributor.authorMissiakas, Dominique
dc.contributor.authorWinstel, Volker
dc.date.accessioned2021-03-05T11:29:54Z
dc.date.available2021-03-05T11:29:54Z
dc.date.issued2021-01-21
dc.identifier.citationFront Immunol. 2021 Jan 21;11:621733. doi: 10.3389/fimmu.2020.621733.en_US
dc.identifier.pmid33552085
dc.identifier.doi10.3389/fimmu.2020.621733
dc.identifier.urihttp://hdl.handle.net/10033/622774
dc.description.abstractHost cell death programs are fundamental processes that shape cellular homeostasis, embryonic development, and tissue regeneration. Death signaling and downstream host cell responses are not only critical to guide mammalian development, they often act as terminal responses to invading pathogens. Here, we briefly review and contrast how invading pathogens and specifically Staphylococcus aureus manipulate apoptotic, necroptotic, and pyroptotic cell death modes to establish infection. Rather than invading host cells, S. aureus subverts these cells to produce diffusible molecules that cause death of neighboring hematopoietic cells and thus shapes an immune environment conducive to persistence. The exploitation of cell death pathways by S. aureus is yet another virulence strategy that must be juxtaposed to mechanisms of immune evasion, autophagy escape, and tolerance to intracellular killing, and brings us closer to the true portrait of this pathogen for the design of effective therapeutics and intervention strategies.en_US
dc.language.isoenen_US
dc.publisherFrontiersen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectStaphylococcus aureusen_US
dc.subjectabscessen_US
dc.subjectblood stream infectionen_US
dc.subjecthost cell deathen_US
dc.subjectinfectionen_US
dc.subjectpersistenceen_US
dc.titleSelective Host Cell Death by Staphylococcus aureus : A Strategy for Bacterial Persistence.en_US
dc.typeArticleen_US
dc.identifier.eissn1664-3224
dc.contributor.departmentTWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH,Feodor-Lynen Str. 7, 30625 Hannover, Germany.en_US
dc.identifier.journalFrontiers in immunologyen_US
dc.source.volume11
dc.source.beginpage621733
dc.source.endpage
refterms.dateFOA2021-03-05T11:29:55Z
dc.source.journaltitleFrontiers in immunology
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countrySwitzerland


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International