Intestinal Dysbiosis Amplifies Acetaminophen-Induced Acute Liver Injury.

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Authors
Schneider, Kai Markus
Elfers, Carsten
Ghallab, Ahmed
Schneider, Carolin Victoria
Galvez, Eric J C
Mohs, Antje
Gui, Wenfang
Candels, Lena Susanna
Wirtz, Theresa Hildegard
Zuehlke, Sebastian
Issue Date
2020-11-12

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Abstract
To test this hypothesis, we assessed the association of proton pump inhibitor (PPI) or long-term antibiotics (ABx) intake, which have both been linked to intestinal dysbiosis, and occurrence of ALF in the 500,000 participants of the UK BioBank population-based cohort. For functional studies, male Nlrp6-/- mice were used as a dysbiotic mouse model and injected with a sublethal dose of acetaminophen (APAP) or lipopolysaccharide (LPS) to induce ALF.
Citation
Cell Mol Gastroenterol Hepatol. 2020 Nov 12;11(4):909-933. doi: 10.1016/j.jcmgh.2020.11.002. Epub ahead of print.
Affiliation
HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.
Publisher
Elsevier
Journal
Cellular and molecular gastroenterology and hepatology
URI
http://hdl.handle.net/10033/622783
DOI
10.1016/j.jcmgh.2020.11.002
PubMed ID
33189892
Type
Article
Language
en
EISSN
2352-345X
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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International