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dc.contributor.authorSellers, Subhashini A
dc.contributor.authorFischer, William A
dc.contributor.authorHeise, Mark T
dc.contributor.authorSchughart, Klaus
dc.date.accessioned2021-03-23T14:52:10Z
dc.date.available2021-03-23T14:52:10Z
dc.date.issued2021-02-24
dc.identifier.citationSci Rep. 2021 Feb 24;11(1):4465. doi: 10.1038/s41598-021-83876-9.en_US
dc.identifier.pmid33627703
dc.identifier.doi10.1038/s41598-021-83876-9
dc.identifier.urihttp://hdl.handle.net/10033/622788
dc.description.abstractRespiratory viral (RV) infections represent a major threat for human health worldwide. Persons with HIV (PWH) have a compromised immune response and are thought to be at higher risk for severe RV disease. However, very little is known about the host immune response to RV infection in PWH. Here, we investigated gene expression changes in the peripheral blood of PWH co-infected with RV. Only very few differentially expressed genes could be detected between PWH with and without RV infection, suggesting that the immune response to RV in PWH is strongly dampened. Our data provides important insights into the host response to RV infections in HIV patients.en_US
dc.language.isoenen_US
dc.publisherNature researchen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleHighly dampened blood transcriptome response in HIV patients after influenza infection.en_US
dc.typeArticleen_US
dc.identifier.eissn2045-2322
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalScientific reportsen_US
dc.source.volume11
dc.source.issue1
dc.source.beginpage4465
dc.source.endpage
refterms.dateFOA2021-03-23T14:52:11Z
dc.source.journaltitleScientific reports
dc.source.countryEngland


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International