The Total Synthesis of Chondrochloren A.

Linne, Yannick; Bonandi, Elisa; Tabet, Christopher; Geldsetzer, Jan; Kalesse, Markus

dc.contributor.author	Linne, Yannick
dc.contributor.author	Bonandi, Elisa
dc.contributor.author	Tabet, Christopher
dc.contributor.author	Geldsetzer, Jan
dc.contributor.author	Kalesse, Markus
dc.date.accessioned	2021-03-31T14:36:50Z
dc.date.available	2021-03-31T14:36:50Z
dc.date.issued	2021-02-25
dc.identifier.citation	Angew Chem Int Ed Engl. 2021 Mar 22;60(13):6938-6942. doi: 10.1002/anie.202016072. Epub 2021 Feb 25.	en_US
dc.identifier.pmid	33450788
dc.identifier.doi	10.1002/anie.202016072
dc.identifier.uri	http://hdl.handle.net/10033/622811
dc.description.abstract	The first total synthesis of chondrochloren A is accomplished using a 1,2-metallate rearrangement addition as an alternative for the Nozaki-Hiyama-Kishi reaction. This transformation also avoids the inherent challenges of this polyketide segment and provides a new, unprecedented strategy to assemble polyketidal frameworks. The formation of the Z-enamide is accomplished using a Z-selective cross coupling of the corresponding amide to a Z-vinyl bromide.	en_US
dc.language.iso	en	en_US
dc.publisher	Wiley-VCH	en_US
dc.rights	Attribution 4.0 International	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.subject	1,2-metallate rearrangement	en_US
dc.subject	Hoppe anion	en_US
dc.subject	chondrochloren	en_US
dc.subject	natural product synthesis	en_US
dc.subject	polyketides	en_US
dc.title	The Total Synthesis of Chondrochloren A.	en_US
dc.type	Article	en_US
dc.identifier.eissn	1521-3773
dc.contributor.department	HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.	en_US
dc.identifier.journal	Angewandte Chemie (International ed. in English)	en_US
dc.source.volume	60
dc.source.issue	13
dc.source.beginpage	6938
dc.source.endpage	6942
refterms.dateFOA	2021-03-31T14:36:51Z
dc.source.journaltitle	Angewandte Chemie (International ed. in English)
dc.source.country	Germany