Lymph node stromal cell subsets-Emerging specialists for tailored tissue-specific immune responses.
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Issue Date
2021-02-25
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The effective priming of adaptive immune responses depends on the precise dispatching of lymphocytes and antigens into and within lymph nodes (LNs), which are strategically dispersed throughout the body. Over the past decade, a growing body of evidence has advanced our understanding of lymph node stromal cells (LNSCs) from viewing them as mere accessory cells to seeing them as critical cellular players for the modulation of adaptive immune responses. In this review, we summarize current advances on the pivotal roles that LNSCs play in orchestrating adaptive immune responses during homeostasis and infection, and highlight the imprinting of location-specific information by micro-environmental cues into LNSCs, thereby tailoring tissue-specific immune responses.Citation
Int J Med Microbiol. 2021 Feb 25;311(3):151492. doi: 10.1016/j.ijmm.2021.151492. Epub ahead of print.Affiliation
HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.Publisher
ElsevierPubMed ID
33676241Type
ArticleLanguage
enEISSN
1618-0607ae974a485f413a2113503eed53cd6c53
10.1016/j.ijmm.2021.151492
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