Show simple item record

dc.contributor.authorPetry, Monique
dc.contributor.authorPalus, Martin
dc.contributor.authorLeitzen, Eva
dc.contributor.authorMitterreiter, Johanna Gracia
dc.contributor.authorHuang, Bei
dc.contributor.authorKröger, Andrea
dc.contributor.authorVerjans, Georges M G M
dc.contributor.authorBaumgärtner, Wolfgang
dc.contributor.authorRimmelzwaan, Guus F
dc.contributor.authorRůžek, Daniel
dc.contributor.authorOsterhaus, Albert
dc.contributor.authorPrajeeth, Chittappen Kandiyil
dc.date.accessioned2021-04-01T11:12:38Z
dc.date.available2021-04-01T11:12:38Z
dc.date.issued2021-02-26
dc.identifier.citation. Vaccines (Basel). 2021 Feb 26;9(3):196. doi: 10.3390/vaccines9030196.en_US
dc.identifier.issn2076-393X
dc.identifier.pmid33652698
dc.identifier.doi10.3390/vaccines9030196
dc.identifier.urihttp://hdl.handle.net/10033/622815
dc.description.abstractTick-borne encephalitis virus (TBEV) is a leading cause of vector-borne viral encephalitis with expanding endemic regions across Europe. In this study we tested in mice the efficacy of preinfection with a closely related low-virulent flavivirus, Langat virus (LGTV strain TP21), or a naturally avirulent TBEV strain (TBEV-280) in providing protection against lethal infection with the highly virulent TBEV strain (referred to as TBEV-Hypr). We show that prior infection with TP21 or TBEV-280 is efficient in protecting mice from lethal TBEV-Hypr challenge. Histopathological analysis of brains from nonimmunized mice revealed neuronal TBEV infection and necrosis. Neuroinflammation, gliosis, and neuronal necrosis was however also observed in some of the TP21 and TBEV-280 preinfected mice although at reduced frequency as compared to the nonimmunized TBEV-Hypr infected mice. qPCR detected the presence of viral RNA in the CNS of both TP21 and TBEV-280 immunized mice after TBEV-Hypr challenge, but significantly reduced compared to mock-immunized mice. Our results indicate that although TBEV-Hypr infection is effectively controlled in the periphery upon immunization with low-virulent LGTV or naturally avirulent TBEV 280, it may still enter the CNS of these animals. These findings contribute to our understanding of causes for vaccine failure in individuals vaccinated with TBE vaccines.en_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCNSen_US
dc.subjectLangat virusen_US
dc.subjectneuronal damageen_US
dc.subjecttick-borne encephalitis virusen_US
dc.subjectvirus induced immunityen_US
dc.titleImmunity to TBEV Related Flaviviruses with Reduced Pathogenicity Protects Mice from Disease but Not from TBEV Entry into the CNS.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalVaccinesen_US
dc.source.volume9
dc.source.issue3
refterms.dateFOA2021-04-01T11:12:39Z
dc.source.journaltitleVaccines
dc.source.countrySwitzerland


Files in this item

Thumbnail
Name:
Petry et al.pdf
Size:
3.386Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International