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dc.contributor.authorElfaki, Yassin
dc.contributor.authorRobert, Philippe A
dc.contributor.authorBinz, Christoph
dc.contributor.authorFalk, Christine S
dc.contributor.authorBruder, Dunja
dc.contributor.authorPrinz, Immo
dc.contributor.authorFloess, Stefan
dc.contributor.authorMeyer-Hermann, Michael
dc.contributor.authorHuehn, Jochen
dc.identifier.citationEur J Immunol. 2021 Feb 26. doi: 10.1002/eji.202048981. Epub ahead of print.en_US
dc.description.abstractFoxp3+ Treg cells, which are crucial for maintenance of self-tolerance, mainly develop within the thymus, where they arise from CD25+ Foxp3- or CD25- Foxp3+ Treg cell precursors. Although it is known that infections can cause transient thymic involution, the impact of infection-induced thymus atrophy on thymic Treg (tTreg) cell development is unknown. Here, we infected mice with influenza A virus (IAV) and studied thymocyte population dynamics post infection. IAV infection caused a massive, but transient thymic involution, dominated by a loss of CD4+ CD8+ double-positive (DP) thymocytes, which was accompanied by a significant increase in the frequency of CD25+ Foxp3+ tTreg cells. Differential apoptosis susceptibility could be experimentally excluded as a reason for the relative tTreg cell increase, and mathematical modeling suggested that enhanced tTreg cell generation cannot explain the increased frequency of tTreg cells. Yet, an increased death of DP thymocytes and augmented exit of single-positive (SP) thymocytes was suggested to be causative. Interestingly, IAV-induced thymus atrophy resulted in a significantly reduced T-cell receptor (TCR) repertoire diversity of newly produced tTreg cells. Taken together, IAV-induced thymus atrophy is substantially altering the dynamics of major thymocyte populations, finally resulting in a relative increase of tTreg cells with an altered TCR repertoire.en_US
dc.rightsAttribution 4.0 International*
dc.subjectFoxp3+ Treg cells ⋅ Influenza A virus ⋅ Mathematical modeling ⋅ Ordinary differential equations ⋅ Thymus atrophyen_US
dc.titleInfluenza A virus-induced thymus atrophy differentially affects dynamics of conventional and regulatory T-cell development in mice.en_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.; BRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56,38106 Braunschweig, Germany.en_US
dc.identifier.journalEuropean journal of immunologyen_US
dc.source.journaltitleEuropean journal of immunology

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Attribution 4.0 International
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