Local pulmonary drug delivery in the preterm rabbit: feasibility and efficacy of daily intratracheal injections.
Name:
Salaets et al.pdf
Size:
1.615Mb
Format:
PDF
Description:
delayed Open Access publication
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Salaets, ThomasGie, André
Jimenez, Julio
Aertgeerts, Margo
Gheysens, Olivier
Vande Velde, Greetje
Koole, Michel
Murgia, Xabi
Casiraghi, Costanza
Ricci, Francesca
Salomone, Fabrizio
Villetti, Gino
Allegaert, Karel
Deprest, Jan
Toelen, Jaan
Issue Date
2019-01-24
Metadata
Show full item recordAbstract
Recent clinical trials in newborns have successfully used surfactant as a drug carrier for an active compound, to minimize systemic exposure. To investigate the translational potential of surfactant-compound mixtures and other local therapeutics, a relevant animal model is required in which intratracheal administration for maximal local deposition is technically possible and well tolerated. Preterm rabbit pups (born at 28 days of gestation) were exposed to either hyperoxia or normoxia and randomized to receive daily intratracheal surfactant, daily intratracheal saline, or no injections for 7 days. At day 7, the overall lung function and morphology were assessed. Efficacy in terms of distribution was assessed by micro-PET-CT on both day 0 and day 7. Lung function as well as parenchymal and vascular structure were altered by hyperoxia, thereby reproducing a phenotype reminiscent of bronchopulmonary dysplasia (BPD). Neither intratracheal surfactant nor saline affected the survival or the hyperoxia-induced BPD phenotype of the pups. Using PET-CT, we demonstrate that 82.5% of the injected radioactive tracer goes and remains in the lungs, with a decrease of only 4% after 150 min. Surfactant and saline can safely and effectively be administered in spontaneously breathing preterm rabbits. The described model and method enable researchers to evaluate intratracheal pharmacological interventions for the treatment of BPD.Citation
Am J Physiol Lung Cell Mol Physiol. 2019 Apr 1;316(4):L589-L597. doi: 10.1152/ajplung.00255.2018. Epub 2019 Jan 24.Affiliation
HIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.Publisher
American Physiological SocietyPubMed ID
30675804Type
ArticleLanguage
enEISSN
1522-1504ae974a485f413a2113503eed53cd6c53
10.1152/ajplung.00255.2018
Scopus Count
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International