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dc.contributor.authorRoth, Stefan
dc.contributor.authorCao, Jiayu
dc.contributor.authorSingh, Vikramjeet
dc.contributor.authorTiedt, Steffen
dc.contributor.authorHundeshagen, Gabriel
dc.contributor.authorLi, Ting
dc.contributor.authorBoehme, Julia D
dc.contributor.authorChauhan, Dhruv
dc.contributor.authorZhu, Jie
dc.contributor.authorRicci, Alessio
dc.contributor.authorGorka, Oliver
dc.contributor.authorAsare, Yaw
dc.contributor.authorYang, Jun
dc.contributor.authorLopez, Mary S
dc.contributor.authorRehberg, Markus
dc.contributor.authorBruder, Dunja
dc.contributor.authorZhang, Shengxiang
dc.contributor.authorGroß, Olaf
dc.contributor.authorDichgans, Martin
dc.contributor.authorHornung, Veit
dc.contributor.authorLiesz, Arthur
dc.date.accessioned2021-04-19T12:18:57Z
dc.date.available2021-04-19T12:18:57Z
dc.date.issued2021-03-04
dc.identifier.citationImmunity. 2021 Apr 13;54(4):648-659.e8. doi: 10.1016/j.immuni.2021.02.004. Epub 2021 Mar 4.en_US
dc.identifier.pmid33667383
dc.identifier.doi10.1016/j.immuni.2021.02.004
dc.identifier.urihttp://hdl.handle.net/10033/622831
dc.description.abstractLoss of lymphocytes, particularly T cell apoptosis, is a central pathological event after severe tissue injury that is associated with increased susceptibility for life-threatening infections. The precise immunological mechanisms leading to T cell death after acute injury are largely unknown. Here, we identified a monocyte-T cell interaction driving bystander cell death of T cells in ischemic stroke and burn injury. Specifically, we found that stroke induced a FasL-expressing monocyte population, which led to extrinsic T cell apoptosis. This phenomenon was driven by AIM2 inflammasome-dependent interleukin-1β (IL-1β) secretion after sensing cell-free DNA. Pharmacological inhibition of this pathway improved T cell survival and reduced post-stroke bacterial infections. As such, this study describes inflammasome-dependent monocyte activation as a previously unstudied cause of T cell death after injury and challenges the current paradigms of post-injury lymphopenia.en_US
dc.language.isoenen_US
dc.publisherElsevier (Cell Press)en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAIM2en_US
dc.subjectFasen_US
dc.subjectIL-1en_US
dc.subjectT cellen_US
dc.subjectburnen_US
dc.subjectcell deathen_US
dc.subjectinflammasomeen_US
dc.subjectstrokeen_US
dc.subjecttissue injuryen_US
dc.titlePost-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade.en_US
dc.typeArticleen_US
dc.identifier.eissn1097-4180
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalImmunityen_US
dc.source.volume54
dc.source.issue4
dc.source.beginpage648
dc.source.endpage659.e8
dc.source.journaltitleImmunity
dc.source.countryUnited States


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