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dc.contributor.authorHarms, Karen
dc.contributor.authorMilic, Andrea
dc.contributor.authorStchigel, Alberto M
dc.contributor.authorStadler, Marc
dc.contributor.authorSurup, Frank
dc.contributor.authorMarin-Felix, Yasmina
dc.date.accessioned2021-04-22T13:00:21Z
dc.date.available2021-04-22T13:00:21Z
dc.date.issued2021-03-03
dc.identifier.citationJ Fungi (Basel). 2021 Mar 3;7(3):181. doi: 10.3390/jof7030181..en_US
dc.identifier.pmid33802411
dc.identifier.doi10.3390/jof7030181
dc.identifier.urihttp://hdl.handle.net/10033/622838
dc.description.abstractTriangularia mangenotti was analyzed for the production of secondary metabolites, resulting in the isolation of known zopfinol (1) and its new derivatives zopfinol B-C (2-4), the 10-membered lactones 7-O-acetylmultiplolide A (5) and 8-O-acetylmultiplolide A (6), together with sordarin (7), sordarin B (8), and hypoxysordarin (9). The absolute configuration of 1 was elucidated by the synthesis of MPTA-esters. Compound 1 showed antimicrobial activity against the Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus and the fungus Mucor hiemalis. While 4 was weakly antibacterial, 3 showed stronger antibiotic activity against the Gram-positive bacteria and weak antifungal activity against M. hiemalis and Rhodotorula glutinis. We furthermore observed the cytotoxicity of 1, 3 and 4 against the mammalian cell lines KB3.1 and L929. Moreover, the new genus Pseudorhypophila is introduced herein to accommodate Triangularia mangenotii together with several species of Zopfiella-Z. marina, Z. pilifera, and Z. submersa. These taxa formed a well-supported monophyletic clade in the recently introduced family Navicularisporaceae, located far from the type species of the respective original genera, in a phylogram based on the combined dataset sequences of the internal transcribed spacer region (ITS), the nuclear rDNA large subunit (LSU), and fragments of the ribosomal polymerase II subunit 2 (rpb2) and β-tubulin (tub2) genes. Zopfiella submersa is synonymized with P. marina due to the phylogenetic and morphological similarity. The isolation of zopfinols 1-4 and sordarins 7-9 confirms the potential of this fungal order as producers of bioactive compounds and suggests these compounds as potential chemotaxonomic markers.en_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAntimicrobialsen_US
dc.subjectNaviculisporaceaeen_US
dc.subjectSordarialesen_US
dc.subjectcytotoxicityen_US
dc.subjectsecondary metabolitesen_US
dc.subjectsordarinsen_US
dc.titleThree New Derivatives of Zopfinol from Pseudorhypophila Mangenotii gen. et comb. noven_US
dc.typeArticleen_US
dc.identifier.eissn2309-608X
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalJournal of fungi (Basel, Switzerland)en_US
dc.source.volume7
dc.source.issue3
refterms.dateFOA2021-04-22T13:00:22Z
dc.source.journaltitleJournal of fungi (Basel, Switzerland)
dc.source.countrySwitzerland


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