Extracellular vesicles as antigen carriers for novel vaccination avenues.
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Issue Date
2021-03-26
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Antigen delivery has always been a challenge in scientific practice of vaccine formulation. Yet, mammalian extracellular vesicles (EVs) or bacterial membrane vesicles (MVs) provide an innovative avenue for safe and effective delivery of antigenic material. They include intrinsically loaded antigens from EV-secreting cells or extrinsically loaded antigens onto pre-formed vesicles. Interestingly, many studies shed light on potential novel anti-cancer vaccination immunotherapy for therapeutic applications from mammalian cell host-derived EVs, as well as conventional vaccination for prophylactic applications using bacterial cell-derived MVs against infectious diseases. Here, we discuss the rationale, status quo and potential for both vaccine applications using EVs.Citation
Adv Drug Deliv Rev. 2021 Mar 26;173:164-180. doi: 10.1016/j.addr.2021.03.016. Epub ahead of print.Affiliation
HIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.Publisher
ElsevierJournal
Advanced drug delivery reviewsPubMed ID
33775707Type
ReviewLanguage
enEISSN
1872-8294ae974a485f413a2113503eed53cd6c53
10.1016/j.addr.2021.03.016
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