Bacterial extracellular vesicles: Understanding biology promotes applications as nanopharmaceuticals.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractExtracellular vesicle (EV)-mediated communication between proximal and distant cells is a highly conserved characteristic in all of the life domains, including bacteria. These vesicles that contain a variety of biomolecules, such as proteins, lipids, nucleic acids, and small-molecule metabolites play a key role in the biology of bacteria. They are one of the key underlying mechanisms behind harmful or beneficial effects of many pathogenic, symbiont, and probiotic bacteria. These nanoscale EVs mediate extensive crosstalk with mammalian cells and deliver their cargos to the host. They are stable in physiological condition, can encapsulate diverse biomolecules and nanoparticles, and their surface could be engineered with available technologies. Based on favorable characteristics of bacterial vesicles, they can be harnessed for designing a diverse range of therapeutics and diagnostics for treatment of disorders including tumors and resistant infections. However, technical limitations for their production, purification, and characterization must be addressed in future studies.
CitationAdv Drug Deliv Rev. 2021 Mar 25;173:125-140. doi: 10.1016/j.addr.2021.03.012. Epub ahead of print.
AffiliationHIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.
JournalAdvanced drug delivery reviews
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International
- Bioinspired Extracellular Vesicles: Lessons Learned From Nature for Biomedicine and Bioengineering.
- Authors: Zinger A, Brozovich A, Pasto A, Sushnitha M, Martinez JO, Evangelopoulos M, Boada C, Tasciotti E, Taraballi F
- Issue date: 2020 Oct 30
- Analysis of the <i>Escherichia coli</i> extracellular vesicle proteome identifies markers of purity and culture conditions.
- Authors: Hong J, Dauros-Singorenko P, Whitcombe A, Payne L, Blenkiron C, Phillips A, Swift S
- Issue date: 2019
- The Evolving Role of Caveolin-1: A Critical Regulator of Extracellular Vesicles.
- Authors: Ni K, Wang C, Carnino JM, Jin Y
- Issue date: 2020 Nov 4
- Drug Delivery with Extracellular Vesicles: From Imagination to Innovation.
- Authors: de Jong OG, Kooijmans SAA, Murphy DE, Jiang L, Evers MJW, Sluijter JPG, Vader P, Schiffelers RM
- Issue date: 2019 Jul 16
- Chromatography and its hyphenation to mass spectrometry for extracellular vesicle analysis.
- Authors: Pocsfalvi G, Stanly C, Fiume I, Vékey K
- Issue date: 2016 Mar 25