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dc.contributor.authorJahromi, Leila Pourtalebi
dc.contributor.authorFuhrmann, Gregor
dc.date.accessioned2021-04-23T14:23:59Z
dc.date.available2021-04-23T14:23:59Z
dc.date.issued2021-03-25
dc.identifier.citationAdv Drug Deliv Rev. 2021 Mar 25;173:125-140. doi: 10.1016/j.addr.2021.03.012. Epub ahead of print.en_US
dc.identifier.pmid33774113
dc.identifier.doi10.1016/j.addr.2021.03.012
dc.identifier.urihttp://hdl.handle.net/10033/622841
dc.description.abstractExtracellular vesicle (EV)-mediated communication between proximal and distant cells is a highly conserved characteristic in all of the life domains, including bacteria. These vesicles that contain a variety of biomolecules, such as proteins, lipids, nucleic acids, and small-molecule metabolites play a key role in the biology of bacteria. They are one of the key underlying mechanisms behind harmful or beneficial effects of many pathogenic, symbiont, and probiotic bacteria. These nanoscale EVs mediate extensive crosstalk with mammalian cells and deliver their cargos to the host. They are stable in physiological condition, can encapsulate diverse biomolecules and nanoparticles, and their surface could be engineered with available technologies. Based on favorable characteristics of bacterial vesicles, they can be harnessed for designing a diverse range of therapeutics and diagnostics for treatment of disorders including tumors and resistant infections. However, technical limitations for their production, purification, and characterization must be addressed in future studies.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAntimicrobialsen_US
dc.subjectBacterial extracellular vesiclesen_US
dc.subjectBioengineeringen_US
dc.subjectBiogenic nanotherapeuticsen_US
dc.subjectBioinspireden_US
dc.subjectDrug deliveryen_US
dc.subjectOuter membrane vesiclesen_US
dc.titleBacterial extracellular vesicles: Understanding biology promotes applications as nanopharmaceuticals.en_US
dc.typeReviewen_US
dc.identifier.eissn1872-8294
dc.contributor.departmentHIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.en_US
dc.identifier.journalAdvanced drug delivery reviewsen_US
dc.source.volume173
dc.source.beginpage125
dc.source.endpage140
dc.source.journaltitleAdvanced drug delivery reviews
dc.source.countryNetherlands


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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International