Secondary metabolites of Phlebopus species from Northern Thailand
dc.contributor.author | Chuankid, Boontiya | |
dc.contributor.author | Schrey, Hedda | |
dc.contributor.author | Thongbai, Benjarong | |
dc.contributor.author | Raspé, Olivier | |
dc.contributor.author | Arnold, Norbert | |
dc.contributor.author | Hyde, Kevin David | |
dc.contributor.author | Stadler, Marc | |
dc.date.accessioned | 2021-04-27T14:38:05Z | |
dc.date.available | 2021-04-27T14:38:05Z | |
dc.date.issued | 2020-12-01 | |
dc.identifier.citation | d. Mycol Progress 19, 1525–1536 (2020). https://doi.org/10.1007/s11557-020-01643-y. | en_US |
dc.identifier.issn | 1617416X | |
dc.identifier.doi | 10.1007/s11557-020-01643-y | |
dc.identifier.uri | http://hdl.handle.net/10033/622848 | |
dc.description.abstract | Submerged cultures of the edible mushrooms Phlebopus portentosus and Phlebopus spongiosus were screened for their secondary metabolites by HPLC-UV/Vis and HR-LC-ESI-MS. Two new compounds, 9′-hydroxyphenyl pulvinone (1), containing an unusual pulvinone structure, and phlebopyron (2), together with the seven known pigments, atromentic acid (3), xerocomic acid (4), variegatic acid (5), methyl atromentate (6), methyl isoxerocomate (7), methyl variegatate (8), and variegatorubin (9) were isolated from the cultures. Their structures were assigned on the basis of extensive 1D/2D NMR spectroscopic analyses, as well as HR-ESI-MS, and HR-ESI-MS/MS measurements. Furthermore, the isolated compounds were evaluated for their antimicrobial and cytotoxic properties. 9′-hydroxyphenyl pulvinone (1), xerocomic acid (4), and methyl variegatate (8) exhibited weak to moderate cytotoxic activities against several tumor cell lines. The present paper provides a comprehensive characterization of pigments from the class of pulvinic acids that are present in the basidiomes of many edible bolete species. | en_US |
dc.description.sponsorship | Thailand Research Fund | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer.com | en_US |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Basidiomycota | en_US |
dc.subject | Boletales | en_US |
dc.subject | Edible mushrooms | en_US |
dc.subject | Pulvinic acid derivatives | en_US |
dc.subject | Secondary metabolites | en_US |
dc.subject | Structure elucidation | en_US |
dc.title | Secondary metabolites of Phlebopus species from Northern Thailand | en_US |
dc.type | Article | en_US |
dc.identifier.eissn | 18618952 | |
dc.contributor.department | HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany. | en_US |
dc.identifier.journal | Mycological Progress | en_US |
dc.identifier.eid | 2-s2.0-85097148221 | |
dc.identifier.scopusid | SCOPUS_ID:85097148221 | |
dc.source.volume | 19 | |
dc.source.issue | 12 | |
dc.source.beginpage | 1525 | |
dc.source.endpage | 1536 | |
refterms.dateFOA | 2021-04-27T14:38:06Z | |
dc.source.journaltitle | Mycological Progress |