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dc.contributor.authorDelacher, Michael
dc.contributor.authorSimon, Malte
dc.contributor.authorSanderink, Lieke
dc.contributor.authorHotz-Wagenblatt, Agnes
dc.contributor.authorWuttke, Marina
dc.contributor.authorSchambeck, Kathrin
dc.contributor.authorSchmidleithner, Lisa
dc.contributor.authorBittner, Sebastian
dc.contributor.authorPant, Asmita
dc.contributor.authorRitter, Uwe
dc.contributor.authorHehlgans, Thomas
dc.contributor.authorRiegel, Dania
dc.contributor.authorSchneider, Verena
dc.contributor.authorGroeber-Becker, Florian Kai
dc.contributor.authorEigenberger, Andreas
dc.contributor.authorGebhard, Claudia
dc.contributor.authorStrieder, Nicholas
dc.contributor.authorFischer, Alexander
dc.contributor.authorRehli, Michael
dc.contributor.authorHoffmann, Petra
dc.contributor.authorEdinger, Matthias
dc.contributor.authorStrowig, Till
dc.contributor.authorHuehn, Jochen
dc.contributor.authorSchmidl, Christian
dc.contributor.authorWerner, Jens M
dc.contributor.authorPrantl, Lukas
dc.contributor.authorBrors, Benedikt
dc.contributor.authorImbusch, Charles D
dc.contributor.authorFeuerer, Markus
dc.date.accessioned2021-04-29T07:07:00Z
dc.date.available2021-04-29T07:07:00Z
dc.date.issued2021-03-30
dc.identifier.citationImmunity. 2021 Apr 13;54(4):702-720.e17. doi: 10.1016/j.immuni.2021.03.007. Epub 2021 Mar 30.en_US
dc.identifier.pmid33789089
dc.identifier.doi10.1016/j.immuni.2021.03.007
dc.identifier.urihttp://hdl.handle.net/10033/622851
dc.description.abstractMurine regulatory T (Treg) cells in tissues promote tissue homeostasis and regeneration. We sought to identify features that characterize human Treg cells with these functions in healthy tissues. Single-cell chromatin accessibility profiles of murine and human tissue Treg cells defined a conserved, microbiota-independent tissue-repair Treg signature with a prevailing footprint of the transcription factor BATF. This signature, combined with gene expression profiling and TCR fate mapping, identified a population of tissue-like Treg cells in human peripheral blood that expressed BATF, chemokine receptor CCR8 and HLA-DR. Human BATF+CCR8+ Treg cells from normal skin and adipose tissue shared features with nonlymphoid T follicular helper-like (Tfh-like) cells, and induction of a Tfh-like differentiation program in naive human Treg cells partially recapitulated tissue Treg regenerative characteristics, including wound healing potential. Human BATF+CCR8+ Treg cells from healthy tissue share features with tumor-resident Treg cells, highlighting the importance of understanding the context-specific functions of these cells.en_US
dc.language.isoenen_US
dc.publisherCell Pressen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleSingle-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells.en_US
dc.typeArticleen_US
dc.identifier.eissn1097-4180
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalImmunityen_US
dc.source.volume54
dc.source.issue4
dc.source.beginpage702
dc.source.endpage720.e17
refterms.dateFOA2021-04-29T07:07:00Z
dc.source.journaltitleImmunity
dc.source.countryUnited States


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International