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dc.contributor.authorRichter, Maximilian
dc.contributor.authorVader, Pieter
dc.contributor.authorFuhrmann, Gregor
dc.date.accessioned2021-05-07T08:40:38Z
dc.date.available2021-05-07T08:40:38Z
dc.date.issued2021-04-06
dc.identifier.citationAdv Drug Deliv Rev. 2021 Apr 6;173:416-426. doi: 10.1016/j.addr.2021.03.020. Epub ahead of print.en_US
dc.identifier.pmid33831479
dc.identifier.doi10.1016/j.addr.2021.03.020
dc.identifier.urihttp://hdl.handle.net/10033/622860
dc.description.abstractExtracellular vesicles (EVs) are cell-derived nanoparticles that are important mediators in intercellular communication. This function makes them auspicious candidates for therapeutic and drug-delivery applications. Among EVs, mammalian cell derived EVs and outer membrane vesicles (OMVs) produced by gram-negative bacteria are the most investigated candidates for pharmaceutical applications. To further optimize their performance and to utilize their natural abilities, researchers have strived to equip EVs with new moieties on their surface while preserving the integrity of the vesicles. The aim of this review is to give a comprehensive overview of techniques that can be used to introduce these moieties to the vesicle surface. Approaches can be classified in regards to whether they take place before or after the isolation of EVs. The producing cells can be subjected to genetic manipulation or metabolic engineering to produce surface modified vesicles or EVs are engineered after their isolation by physical or chemical means. Here, the advantages and disadvantages of these processes and their applicability for the development of EVs as therapeutic agents are discussed.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectDrug deliveryen_US
dc.subjectExosomesen_US
dc.subjectExtracellular vesiclesen_US
dc.subjectFluorescent labelingen_US
dc.subjectOuter membrane vesiclesen_US
dc.subjectSurface functionalizationen_US
dc.subjectTargetingen_US
dc.titleApproaches to surface engineering of extracellular vesicles.en_US
dc.typeReviewen_US
dc.identifier.eissn1872-8294
dc.contributor.departmentHIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.en_US
dc.identifier.journalAdvanced drug delivery reviewsen_US
dc.source.volume173
dc.source.beginpage416
dc.source.endpage426
dc.source.journaltitleAdvanced drug delivery reviews
dc.source.countryNetherlands


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International