Formulation and evaluation of transdermal nanogel for delivery of artemether.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsNnamani, Petra O
Ugwu, Agatha A
Nnadi, Ogechukwu H
Kenechukwu, Franklin C
Ofokansi, Kenneth C
Attama, Anthony A
MetadataShow full item record
Abstractrtemether (ART) is second to artesunate in being the most widely used derivatives of artemisinin in combination therapy of malaria. Nanostructured lipid carrier (NLC) formulations were prepared following our previous report using optimized ART concentration of 0.25 g dissolved in 5% w/v mixture of solid (Gelucire 43/01 and Phospholipon 85G) and liquid (Transcutol) lipids at 90 °C. An aqueous surfactant phase at 90 °C was added (dropwise) under magnetic stirring (1000 rpm) for 5 min. The pre-emulsion was speedily homogenized at 28,000 rpm for 15 min and further probe sonicated at 60% amplitude (15 min). Resultant sample was cooled at room temperature and frozen at - 80 °C prior to lyophilization. The freeze-dried sample was used for solid-state characterization as well as in the formulation of transdermal nanogels using three polymers (Carbopol 971P, Poloxamer 407, and Prosopis africana peel powder) to embed the ART-NLC, using ethanol as a penetration enhancer. Transdermal ART-nanogels were characterized accordingly (physical examination, pH, drug content, rheology, spreadability, stability, particle size and morphology, skin irritation, in vitro and ex vivo skin permeation, and analysis of permeation data), P < 0.05. Results indicated that ART nanogels showed good encapsulation, drug release, pH-dependent swelling, stability, and tolerability. Overall, ART nanogels prepared from Poloxamer 407 showed the most desirable drug permeation, pH, swellability, spreadability, viscosity, and transdermal antiplasmodial properties superior to PAPP-ANG > C971P-ANG. A two-patch/week concurrent application of the studied nanogels could offer 100% cure of malaria as a lower-dose (50 mg ART) patient-friendly regimen devoid of the drug's many side effects.
CitationDrug Deliv Transl Res. 2021 Mar 19. doi: 10.1007/s13346-021-00951-4. Epub ahead of print.
AffiliationHIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.
The following license files are associated with this item:
- Creative Commons
- Development of artemether-loaded nanostructured lipid carrier (NLC) formulation for topical application.
- Authors: Nnamani PO, Hansen S, Windbergs M, Lehr CM
- Issue date: 2014 Dec 30
- Sustained-release liquisolid compact tablets containing artemether-lumefantrine as alternate-day regimen for malaria treatment to improve patient compliance.
- Authors: Nnamani PO, Ugwu AA, Ibezim EC, Kenechukwu FC, Akpa PA, Ogbonna JN, Obitte NC, Odo AN, Windbergs M, Lehr CM, Attama AA
- Issue date: 2016
- Novel Enhanced Therapeutic Efficacy of Dapoxetine HCl by Nano-Vesicle Transdermal Gel for Treatment of Carrageenan-Induced Rat Paw Edema.
- Authors: Salem HF, Nafady MM, Kharshoum RM, Abd El-Ghafar OA, Farouk HO
- Issue date: 2020 Apr 14
- Formulation, optimization, and in vitro evaluation of nanostructured lipid carriers for topical delivery of Apremilast.
- Authors: Madan JR, Khobaragade S, Dua K, Awasthi R
- Issue date: 2020 May
- Design and Evaluation of Topical Antioxidant Nanogel Formulations.
- Authors: Tetik G, Rençber S, Özoglu ET, Yapar EA, Karavana SY, Özer Ö
- Issue date: 2021 Jan-Feb